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H11HspB8 and Its Herpes Simplex Virus Type 2 Homologue ICP10PK Share Functions That Regulate Cell LifeDeath Decisions and Human Disease
المؤلفون المشاركون
Aurelian, Laure
Laing, Jennifer M.
Lee, Ki Seok
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Small heat shock proteins (sHsp) also known as HspB are a large family of widely expressed proteins that contain a 90 residues domain known as α-crystallin.
Here, we focus on the family member H11/HspB8 and its herpes simplex virus type 2 (HSV-2) homologue ICP10PK, and discuss the possible impact of this relationship on human disease.
H11/HspB8 and ICP10PK are atypical protein kinases.
They share multi-functional activity that encompasses signaling, unfolded protein response (UPR) and the regulation of life cycle potential.
In melanocytes H11/HspB8 causes growth arrest.
It is silenced in a high proportion of melanoma prostate cancer, Ewing’s sarcoma and hematologic malignancies through aberrant DNA methylation.
Its restored expression induces cell death and inhibits tumor growth in xenograft models, identifying H11/HspB8 as a tumor suppressor.
This function involves the activation of multiple and distinct death pathways, all of which initiate with H11/HspB8-mediated phosphorylation of transforming growth factor β-activated kinase 1 (TAK1).
Both ICP10PK and H11/HspB8 were implicated in inflammatory processes that involve dendritic cells activation through Toll-like receptor-dependent pathways and may contribute to the onset of autoimmunity.
The potential evolutionary relationship of H11/HspB8 to ICP10PK, its impact on human disorders and the development of therapeutic strategies are discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aurelian, Laure& Laing, Jennifer M.& Lee, Ki Seok. 2012. H11HspB8 and Its Herpes Simplex Virus Type 2 Homologue ICP10PK Share Functions That Regulate Cell LifeDeath Decisions and Human Disease. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-468754
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aurelian, Laure…[et al.]. H11HspB8 and Its Herpes Simplex Virus Type 2 Homologue ICP10PK Share Functions That Regulate Cell LifeDeath Decisions and Human Disease. Autoimmune Diseases No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-468754
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aurelian, Laure& Laing, Jennifer M.& Lee, Ki Seok. H11HspB8 and Its Herpes Simplex Virus Type 2 Homologue ICP10PK Share Functions That Regulate Cell LifeDeath Decisions and Human Disease. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-468754
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468754
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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