Schwann Cell Migration Induced by Earthworm Extract via Activation of PAs and MMP29 Mediated through ERK12 and p38
المؤلفون المشاركون
Lai, Tung-Yuan
Shih, Ying-Ting
Fang, Wen-Kuei
Chang, Yung-Ming
Huang, Chih-Yang
Tsai, Fuu-Jen
Chen, Yueh-Sheng
Kuo, Wei-Wen
Liu, Chien-Liang
Tsai, Chang-Hai
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-04
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The earthworm, which has stasis removal and wound-healing functions, is a widely used Chinese herbal medicine in China.
Schwann cell migration is critical for the regeneration of injured nerves.
Schwann cells provide an essentially supportive activity for neuron regeneration.
However, the molecular migration mechanisms induced by earthworms in Schwann cells remain unclear.
Here, we investigate the roles of MAPK (ERK1/2, JNK and p38) pathways for earthworm-induced matrix-degrading proteolytic enzyme (PAs and MMP2/9) production in Schwann cells.
Moreover, earthworm induced phosphorylation of ERK1/2 and p38, but not JNK, activate the downstream signaling expression of PAs and MMPs in a time-dependent manner.
Earthworm-stimulated ERK1/2 and p38 phosphorylation was attenuated by pretreatment with U0126 and SB203580, resulting in migration and uPA-related signal pathway inhibition.
The results were confirmed using small interfering ERK1/2 and p38 RNA.
These results demonstrated that earthworms can stimulate Schwann cell migration and up-regulate PAs and MMP2/9 expression mediated through the MAPK pathways, ERK1/2 and p38.
Taken together, our data suggests the MAPKs (ERK1/2, p38)-, PAs (uPA, tPA)-, MMP (MMP2, MMP9) signaling pathway of Schwann cells regulated by earthworms might play a major role in Schwann cell migration and nerve regeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Yung-Ming& Shih, Ying-Ting& Chen, Yueh-Sheng& Liu, Chien-Liang& Fang, Wen-Kuei& Tsai, Chang-Hai…[et al.]. 2011. Schwann Cell Migration Induced by Earthworm Extract via Activation of PAs and MMP29 Mediated through ERK12 and p38. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-468763
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Yung-Ming…[et al.]. Schwann Cell Migration Induced by Earthworm Extract via Activation of PAs and MMP29 Mediated through ERK12 and p38. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-468763
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Yung-Ming& Shih, Ying-Ting& Chen, Yueh-Sheng& Liu, Chien-Liang& Fang, Wen-Kuei& Tsai, Chang-Hai…[et al.]. Schwann Cell Migration Induced by Earthworm Extract via Activation of PAs and MMP29 Mediated through ERK12 and p38. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-468763
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-468763
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر