Use of Charge Transfer Complexation Reactions for the Spectrophotometric Determination of Sumatriptan in Pharmaceuticals
المؤلفون المشاركون
Vinay, Kanakapura B.
Raghu, Madihalli Srinivas
Prashanth, Kudige Nagaraj
Basavaiah, Kanakapura
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Studies were carried out to use the charge-transfer reactions of sumatriptan (SMT), extracted from neutralized sumatriptan succinate (STS), as n-electron donor with the π-acceptor, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and σ-acceptor, and iodine (I2).
The formation of the colored complexes was utilized for the development of simple, rapid, and accurate spectrophotometric methods for the determination of SMT in pure form as well as in its tablets.
The quantification of colored products was made spectrophotometrically at 585 nm for the CT complex formed between SMT and DDQ (DDQ method) and at 375 nm for the CT complex formed between SMT and I2 (I2 method).
Beer’s law is obeyed over the concentration ranges of 4.0–56.0 μg mL−1 and 2.0–28.0 for DDQ and I2, respectively, with correlation coefficients (r) of 0.9997 and 0.9998.
The analytical parameters such as apparent molar absorptivity, Sandell’s sensitivities, and limits of detection (LOD) and quantification (LOQ) are also reported for both methods.
The described methods were successfully applied to the determination of SMT in tablets.
No interference was observed from the common excipients present in tablets.
The reaction stoichiometry in both methods was evaluated by Job’s method of continuous variations and was found to be 1 : 1 (donor : acceptor).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Prashanth, Kudige Nagaraj& Basavaiah, Kanakapura& Raghu, Madihalli Srinivas& Vinay, Kanakapura B.. 2012. Use of Charge Transfer Complexation Reactions for the Spectrophotometric Determination of Sumatriptan in Pharmaceuticals. ISRN Spectroscopy،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-469076
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Prashanth, Kudige Nagaraj…[et al.]. Use of Charge Transfer Complexation Reactions for the Spectrophotometric Determination of Sumatriptan in Pharmaceuticals. ISRN Spectroscopy No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-469076
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Prashanth, Kudige Nagaraj& Basavaiah, Kanakapura& Raghu, Madihalli Srinivas& Vinay, Kanakapura B.. Use of Charge Transfer Complexation Reactions for the Spectrophotometric Determination of Sumatriptan in Pharmaceuticals. ISRN Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-469076
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469076
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر