Tissue Biomarkers in Prognostication of Serous Ovarian Cancer following Neoadjuvant Chemotherapy
المؤلفون المشاركون
Datta Gupta, Siddhartha
Mathur, Sandeep R.
Kalaivani, M.
Kumar, Sunesh
Iyer, Venkateswaran K.
Kumar, Lalit
Khandakar, Binny
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Serous ovarian cancer (SOC) is a significant cause of morbidity and mortality in females with poor prognosis because of advanced stage at presentation.
Recently, neoadjuvant chemotherapy (NACT) is being used for management of advanced SOC, but role of tissue biomarkers in prognostication following NACT is not well established.
The study was conducted on advanced stage SOC patients (n=100) that were treated either conventionally (n=50) or with NACT (n=50), followed by surgery.
In order to evaluate the expression of tissue biomarkers (p53, MIB1, estrogen and progesterone receptors, Her-2/neu, E-cadherin, and Bcl2), immunohistochemistry and semiquantitative scoring were done following morphological examination.
Following NACT, significant differences in tumor histomorphology were observed as compared to the native neoplasms.
MIB 1 was significantly lower in cases treated with NACT and survival outcome was significantly better in cases with low MIB 1.
ER expression was associated with poor overall survival.
No other marker displayed any significant difference in expression or correlation with survival between the two groups.
Immunophenotype of SOC does not differ significantly in samples from cases treated with NACT, compared to upfront surgically treated cases.
The proliferating capacity of the residual tumor cells is less, depicted by low mean MIB1 LI.
MIB 1 and ER inversely correlate with survival.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khandakar, Binny& Mathur, Sandeep R.& Kumar, Lalit& Kumar, Sunesh& Datta Gupta, Siddhartha& Iyer, Venkateswaran K.…[et al.]. 2014. Tissue Biomarkers in Prognostication of Serous Ovarian Cancer following Neoadjuvant Chemotherapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-469077
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khandakar, Binny…[et al.]. Tissue Biomarkers in Prognostication of Serous Ovarian Cancer following Neoadjuvant Chemotherapy. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-469077
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khandakar, Binny& Mathur, Sandeep R.& Kumar, Lalit& Kumar, Sunesh& Datta Gupta, Siddhartha& Iyer, Venkateswaran K.…[et al.]. Tissue Biomarkers in Prognostication of Serous Ovarian Cancer following Neoadjuvant Chemotherapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-469077
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469077
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر