Type 2 Diabetic Patients with Ischemic Stroke : Decreased Insulin Sensitivity and Decreases in Antioxidant Enzyme Activity Are Related to Different Stroke Subtypes
المؤلفون المشاركون
Civcic, Milorad
Colak, Emina
Kostic, Vladimir S.
Aleksic, Sandra
Milicic, Tanja
Covickovic Sternic, Nadezda
Lalic, Katarina
Macesic, Marija
Jotic, Aleksandra
Lalic, Nebojsa M.
Seferovic, Jelena P.
Mijajlovic, Milija
Lukic, Ljiljana
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
We analyzed (a) insulin sensitivity (IS) and (b) glutathione peroxidase (GSH-Px), glutathione reductase (GR), and superoxide dismutase (SOD) antioxidant enzyme activity in type 2 diabetic (T2D) patients with atherothrombotic infarction (ATI) (group A), lacunar infarction (LI) (B), or without stroke (C) and in nondiabetics with ATI (D), LI (E), or without stroke (F).
ATI and LI were confirmed by brain imaging IS levels were determined by minimal model (Si index), and the enzyme activity by spectrophotometry.
In T2D patients, Si was lower in A and B versus C (1.14±0.58, 1.00±0.26 versus 3.14±0.62 min−1/mU/l × 104, P<0.001) and in nondiabetics in D and E versus F (3.38±0.77, 3.03±0.72 versus 6.03±1.69 min−1/mU/l × 104, P<0.001).
Also, GSH-Px and GR activities were lower in A and B versus C (GSH-Px: 21.96±3.56, 22.51±1.23 versus 25.12±1.67; GR: 44.37±3.58, 43.50±2.39 versus 48.58±3.67 U/gHb; P<0.001) and in D and E versus F (GSH-Px: 24.75±3.02, 25.57±1.92 versus 28.56±3.91; GR: 48.27±6.81, 49.17±6.24 versus 53.67±3.96 U/gHb; P<0.001).
Decreases in Si and GR were significantly related to both ATI and LI in T2D.
Our results showed that decreased IS and impaired antioxidant enzymes activity influence ischemic stroke subtypes in T2D.
The influence of insulin resistance might be exerted on the level of glutathione-dependent antioxidant enzymes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jotic, Aleksandra& Covickovic Sternic, Nadezda& Kostic, Vladimir S.& Lalic, Katarina& Milicic, Tanja& Mijajlovic, Milija…[et al.]. 2013. Type 2 Diabetic Patients with Ischemic Stroke : Decreased Insulin Sensitivity and Decreases in Antioxidant Enzyme Activity Are Related to Different Stroke Subtypes. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-469115
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jotic, Aleksandra…[et al.]. Type 2 Diabetic Patients with Ischemic Stroke : Decreased Insulin Sensitivity and Decreases in Antioxidant Enzyme Activity Are Related to Different Stroke Subtypes. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-469115
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jotic, Aleksandra& Covickovic Sternic, Nadezda& Kostic, Vladimir S.& Lalic, Katarina& Milicic, Tanja& Mijajlovic, Milija…[et al.]. Type 2 Diabetic Patients with Ischemic Stroke : Decreased Insulin Sensitivity and Decreases in Antioxidant Enzyme Activity Are Related to Different Stroke Subtypes. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-469115
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469115
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر