Neurite Outgrowth in PC12 Cells Stimulated by Components from Dendranthema × grandiflorum cv. “Mottenohoka” Is Enhanced by Suppressing Phosphorylation of p38MAPK
المؤلفون المشاركون
Koketsu, Mamoru
Tsukagoshi, Hiroyuki
Kozawa, Kunihisa
Kimura, Hirokazu
Ninomiya, Masayuki
Furukawa, Shoei
Nishina, Atsuyoshi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Components from Dendranthema × grandiflorum cv.
“Mottenohoka” that promote neurite outgrowth of PC12 cells were identified and the mechanism of neurite outgrowth stimulated by isolated components was studied.
Components that promoted the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK 1/2) of PC12 cells were isolated.
From various structural analyses, the active components were identified as acacetin and luteolin.
The effects of acacetin or luteolin on PC12 cells were evaluated by electro-blotting and immunostaining.
Slight neurite outgrowth in PC12 cells was observed within 2 days of culture after stimulation by luteolin or acacetin.
However, NGF-stimulation induced remarkable neurite outgrowth in comparison.
Neurite outgrowth by luteolin or acacetin was significantly enhanced by pretreatment with SB203580 (a p38MAPK inhibitor).
The results of this study into the phosphorylation of ERK 1/2 and p38MAPK by flavonoids suggest that the inhibition of p38MAPK phosphorylation may effectively enhance neurite outgrowth.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nishina, Atsuyoshi& Kimura, Hirokazu& Tsukagoshi, Hiroyuki& Kozawa, Kunihisa& Koketsu, Mamoru& Ninomiya, Masayuki…[et al.]. 2013. Neurite Outgrowth in PC12 Cells Stimulated by Components from Dendranthema × grandiflorum cv. “Mottenohoka” Is Enhanced by Suppressing Phosphorylation of p38MAPK. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-469294
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nishina, Atsuyoshi…[et al.]. Neurite Outgrowth in PC12 Cells Stimulated by Components from Dendranthema × grandiflorum cv. “Mottenohoka” Is Enhanced by Suppressing Phosphorylation of p38MAPK. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-469294
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nishina, Atsuyoshi& Kimura, Hirokazu& Tsukagoshi, Hiroyuki& Kozawa, Kunihisa& Koketsu, Mamoru& Ninomiya, Masayuki…[et al.]. Neurite Outgrowth in PC12 Cells Stimulated by Components from Dendranthema × grandiflorum cv. “Mottenohoka” Is Enhanced by Suppressing Phosphorylation of p38MAPK. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-469294
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469294
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر