![](/images/graphics-bg.png)
Protein Sulfhydryl Group Oxidation and Mixed-Disulfide Modifications in Stable and Unstable Human Carotid Plaques
المؤلفون المشاركون
Zinellu, Angelo
Nieddu, Gabriele
Formato, Marilena
Zinellu, Elisabetta
Carru, Ciriaco
Spirito, Rita
De Muro, Pierina
Guarino, Anna
Lepedda, Antonio Junior
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Objectives.
Oxidative stress has been implicated in the outcome of atherosclerotic plaques.
However, at present, no data are available neither on the degree of plaque protein sulfhydryl groups oxidation nor on its relationship with plaque vulnerability.
We investigated the entity of protein-SH oxidative modifications, focusing on low molecular weight thiols adduction, in human carotid plaque extracts in relation to plaque stability/instability.
Methods.
Plaque stability/instability was histologically assessed.
The extent of protein-SH oxidative modifications was established by a differential proteomic approach on fluorescein-5-maleimide-labeled plaque extracts and corresponding plasma samples from 48 endarterectomized patients.
The analysis on protein thiolation was performed by capillary zone electrophoresis.
Results.
We observed a higher protein-SH oxidation of both plasma-derived and topically expressed proteins in unstable plaques, partly due to higher levels of S-thiolation.
Conversely, in plasma, none of the investigated parameters discriminated among patients with stable and unstable plaques.
Conclusions.
Our results suggest the presence of a more pronounced oxidative environment in unstable plaques.
Identifying specific oxidative modifications and understanding their effects on protein function could provide further insight into the relevance of oxidative stress in atherosclerosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lepedda, Antonio Junior& Zinellu, Angelo& Nieddu, Gabriele& Zinellu, Elisabetta& Carru, Ciriaco& Spirito, Rita…[et al.]. 2013. Protein Sulfhydryl Group Oxidation and Mixed-Disulfide Modifications in Stable and Unstable Human Carotid Plaques. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469342
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lepedda, Antonio Junior…[et al.]. Protein Sulfhydryl Group Oxidation and Mixed-Disulfide Modifications in Stable and Unstable Human Carotid Plaques. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-469342
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lepedda, Antonio Junior& Zinellu, Angelo& Nieddu, Gabriele& Zinellu, Elisabetta& Carru, Ciriaco& Spirito, Rita…[et al.]. Protein Sulfhydryl Group Oxidation and Mixed-Disulfide Modifications in Stable and Unstable Human Carotid Plaques. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-469342
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469342
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)