Stability-Indicating HPTLC Method for Determination of Duloxetine Hydrochloride in Bulk Drug and Tablet Formulation
المؤلفون المشاركون
Masroor, Mir Tariq
Shahnawaz, Sheikh
Arora, Vandana
Siddiqui, Abdul Wadood
المصدر
Chromatography Research International
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-17
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
A simple, accurate, precise, sensitive, selective, and stability-indicating high-performance thin-layer chromatographic method was developed and validated for determination of duloxetine hydrochloride both in bulk drug as well as in tablet formulation.
The stationary phase used in our method consisted of HPTLC aluminum plates precoated with silica gel 60F-254, while, chloroform : methanol (8 : 2, v/v) was used as binary mobile phase.
These chromatographic conditions eluted the drug effectively, and distinct compact spots were seen, (Rf, retardation factor, value (0.42 ± 0.20).
Densitometric determination of duloxetine hydrochloride was carried out in the absorbance mode at a wavelength of 217 nm.
The mean value of corelation coefficient; slope and intercept were 0.9962 ± 0.0015, 121.54 ± 0.61, and 987.3 ± 6.17, in the amount range of 600–2000 ng (nanogram) per spot, respectively.
Stress testing validation were performed as per the guidelines of International Conference on Harmonization (ICH) and drug was subjected to stress conditions like acid-hydrolysis, alkali-hydrolysis, oxidation, and thermal degradation.
As the method effectively separated the active drug from its degradation products, it can be employed as a stability-indicating assay method (SIAM) for identification and quantitative determination of duloxetine HCl in bulk drug and tablet dosage formulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shahnawaz, Sheikh& Siddiqui, Abdul Wadood& Masroor, Mir Tariq& Arora, Vandana. 2011. Stability-Indicating HPTLC Method for Determination of Duloxetine Hydrochloride in Bulk Drug and Tablet Formulation. Chromatography Research International،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-469360
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shahnawaz, Sheikh…[et al.]. Stability-Indicating HPTLC Method for Determination of Duloxetine Hydrochloride in Bulk Drug and Tablet Formulation. Chromatography Research International No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-469360
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shahnawaz, Sheikh& Siddiqui, Abdul Wadood& Masroor, Mir Tariq& Arora, Vandana. Stability-Indicating HPTLC Method for Determination of Duloxetine Hydrochloride in Bulk Drug and Tablet Formulation. Chromatography Research International. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-469360
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469360
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر