Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF-α Antibody in Mice
المؤلفون المشاركون
Ohsugi, Yoshiyuki
Inoue, Yoshikazu
Mihara, Masahiko
Hashimoto, Satomi
Kishimoto, Tadamitsu
Sakatani, Mitsunori
Kita, Yoko
Uchiyama, Yasushi
Okada, Masaji
Kanamaru, Noriko
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Our aim was to investigate the effects of IL-6 blockade on the progression of Mycobacterium tuberculosis (TB) and compare them with those of TNF-α blockade in mice.
Methods.
Mice were intravenously infected with TB and injected with antibodies.
Survival was monitored and histological and immunological studies were carried out.
Results.
All anti-IL-6R Ab-treated mice and 8 of 10 control mice survived until sacrificed 224 days after TB challenge, whereas anti-TNF-α Ab-treated mice all died between 120 and 181 days.
Anti-IL-6R Ab-treated mice exhibited no significant differences in TB CFU in organs, including the lungs, and no deterioration in histopathology compared to control mice at 4 weeks.
In contrast, anti-TNF-α Ab-treated mice exhibited increased TB CFU and greater progression of histopathological findings in organs than control mice.
Spleen cells from anti-TNF-α Ab-treated mice had decreased antigen-specific response in IFN-γ release and proliferation assays.
The results in anti-IL-6R Ab-treated mice suggest that spleen cell responses were decreased to a lesser degree.
Similar results were obtained in IL-6 knockout (KO) mice, compared with TNF receptor 1 (TNFR1) KO and TNFR1/IL-6 double KO (DKO) mice.
Conclusion.
IL-6R blockade promotes the progression of TB infection in mice far less than TNF-α blockade.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Okada, Masaji& Kita, Yoko& Kanamaru, Noriko& Hashimoto, Satomi& Uchiyama, Yasushi& Mihara, Masahiko…[et al.]. 2011. Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF-α Antibody in Mice. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-469420
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Okada, Masaji…[et al.]. Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF-α Antibody in Mice. Clinical and Developmental Immunology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-469420
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Okada, Masaji& Kita, Yoko& Kanamaru, Noriko& Hashimoto, Satomi& Uchiyama, Yasushi& Mihara, Masahiko…[et al.]. Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF-α Antibody in Mice. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-469420
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469420
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر