Cytotoxic Activity of Peripheral Blood Mononuclear Leukocytes, Activated by Interleukin-2β-Cyclodextrin Nanocomposition against Androgen Receptor-Negative Prostate Cancers
المؤلفون المشاركون
Sosnov, Andrey V.
Anisimova, Natalia Yu.
Ustyuzhanina, Nadezhda E.
Baronzio, Gianfranco
Kiselevsky, Mikhail V.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Nanocomposition comprised of interleukin-2 in suboptimal noneffective concentration and β-cyclodextrin was studied in vitro.
This preparation as well as interleukin-2 in optimal concentration was shown to increase natural killer activity to K-562 cells and cytotoxicity of activated peripheral blood mononuclear cells (PBMCs) against PC-3 and DU 145 cells.
At the same time β-cyclodextrin or interleukin-2 in equimolar concentrations did not influence the spontaneous killer activity of PBMC.
This combination of cyclodextrin + interleukin-2 led to the decrease of interleukin-2 effective concentration by an order.
This phenomenon could be explained by cyclodextrins ability to promote the formation of nanoparticles with drugs, which results in enhancing their water solubility and bioavailability.
Besides, interleukine-2/β-cyclodextrin nanocomposition as opposed to interleukin-2 alone led to increasing the number of not only lymphocytes, but also macrophages contained in activated PBMC population.
Application of low concentration of interleukin-2 allowing for good clinical efficiency may significantly mitigate the side effects of the drug and enable to develop adoption of immunotherapy for patients with androgen-resistant prostate cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Anisimova, Natalia Yu.& Sosnov, Andrey V.& Ustyuzhanina, Nadezhda E.& Baronzio, Gianfranco& Kiselevsky, Mikhail V.. 2011. Cytotoxic Activity of Peripheral Blood Mononuclear Leukocytes, Activated by Interleukin-2β-Cyclodextrin Nanocomposition against Androgen Receptor-Negative Prostate Cancers. ISRN Oncology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-469488
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Anisimova, Natalia Yu.…[et al.]. Cytotoxic Activity of Peripheral Blood Mononuclear Leukocytes, Activated by Interleukin-2β-Cyclodextrin Nanocomposition against Androgen Receptor-Negative Prostate Cancers. ISRN Oncology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-469488
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Anisimova, Natalia Yu.& Sosnov, Andrey V.& Ustyuzhanina, Nadezhda E.& Baronzio, Gianfranco& Kiselevsky, Mikhail V.. Cytotoxic Activity of Peripheral Blood Mononuclear Leukocytes, Activated by Interleukin-2β-Cyclodextrin Nanocomposition against Androgen Receptor-Negative Prostate Cancers. ISRN Oncology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-469488
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469488
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر