The Annexin A2S100A10 System in Health and Disease : Emerging Paradigms
المؤلفون المشاركون
Huang, Bihui
Santambrogio, Laura
Tsirka, Stella E.
Kraemer, Rosemary
Cesarman-Maus, Gabriela
Zhai, Haiyan
Falcone, Domenick J.
Hedhli, Nadia
Hajjar, Katherine A.
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-14
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Since its discovery as a src kinase substrate more than three decades ago, appreciation for the physiologic functions of annexin A2 and its associated proteins has increased dramatically.
With its binding partner S100A10 (p11), A2 forms a cell surface complex that regulates generation of the primary fibrinolytic protease, plasmin, and is dynamically regulated in settings of hemostasis and thrombosis.
In addition, the complex is transcriptionally upregulated in hypoxia and promotes pathologic neoangiogenesis in the tissues such as the retina.
Dysregulation of both A2 and p11 has been reported in examples of rodent and human cancer.
Intracellularly, A2 plays a critical role in endosomal repair in postarthroplastic osteolysis, and intracellular p11 regulates serotonin receptor activity in psychiatric mood disorders.
In human studies, the A2 system contributes to the coagulopathy of acute promyelocytic leukemia, and is a target of high-titer autoantibodies in patients with antiphospholipid syndrome, cerebral thrombosis, and possibly preeclampsia.
Polymorphisms in the human ANXA2 gene have been associated with stroke and avascular osteonecrosis of bone, two severe complications of sickle cell disease.
Together, these new findings suggest that manipulation of the annexin A2/S100A10 system may offer promising new avenues for treatment of a spectrum of human disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hedhli, Nadia& Falcone, Domenick J.& Huang, Bihui& Cesarman-Maus, Gabriela& Kraemer, Rosemary& Zhai, Haiyan…[et al.]. 2012. The Annexin A2S100A10 System in Health and Disease : Emerging Paradigms. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-469567
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hedhli, Nadia…[et al.]. The Annexin A2S100A10 System in Health and Disease : Emerging Paradigms. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-469567
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hedhli, Nadia& Falcone, Domenick J.& Huang, Bihui& Cesarman-Maus, Gabriela& Kraemer, Rosemary& Zhai, Haiyan…[et al.]. The Annexin A2S100A10 System in Health and Disease : Emerging Paradigms. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-469567
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469567
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر