Clinicopathologic Comparison of High-Dose-Rate Endorectal Brachytherapy versus Conventional Chemoradiotherapy in the Neoadjuvant Setting for Resectable Stages II and III Low Rectal Cancer
المؤلفون المشاركون
Azad, Nilofer S.
Wick, Elizabeth C.
Raman, Siva P.
Singhi, Aatur
Hacker-Prietz, Amy
Herman, Joseph M.
Gearhart, Susan L.
Hruban, Ralph H.
Smith, Jessica A.
Kamel, Ihab R.
Qiu, Haoming
Kumar, Rachit
Wild, Aaron T.
Le, Yi
Diaz, Luis A.
Armour, Elwood P.
Efron, Jonathan
المصدر
International Journal of Surgical Oncology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-08
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Purpose.
To assess for differences in clinical, radiologic, and pathologic outcomes between patients with stage II-III rectal adenocarcinoma treated neoadjuvantly with conventional external beam radiotherapy (3D conformal radiotherapy (3DRT) or intensity-modulated radiotherapy (IMRT)) versus high-dose-rate endorectal brachytherapy (EBT).
Methods.
Patients undergoing neoadjuvant EBT received 4 consecutive daily 6.5 Gy fractions without chemotherapy, while those undergoing 3DRT or IMRT received 28 daily 1.8 Gy fractions with concurrent 5-fluorouracil.
Data was collected prospectively for 7 EBT patients and retrospectively for 25 historical 3DRT/IMRT controls.
Results.
Time to surgery was less for EBT compared to 3DRT and IMRT (P<0.001).
There was a trend towards higher rate of pathologic CR for EBT (P=0.06).
Rates of margin and lymph node positivity at resection were similar for all groups.
Acute toxicity was less for EBT compared to 3DRT and IMRT (P=0.025).
Overall and progression-free survival were noninferior for EBT.
On MRI, EBT achieved similar complete response rate and reduction in tumor volume as 3DRT and IMRT.
Histopathologic comparison showed that EBT resulted in more localized treatment effects and fewer serosal adhesions.
Conclusions.
EBT offers several practical benefits over conventional radiotherapy techniques and appears to be at least as effective against low rectal cancer as measured by short-term outcomes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Smith, Jessica A.& Wild, Aaron T.& Singhi, Aatur& Raman, Siva P.& Qiu, Haoming& Kumar, Rachit…[et al.]. 2012. Clinicopathologic Comparison of High-Dose-Rate Endorectal Brachytherapy versus Conventional Chemoradiotherapy in the Neoadjuvant Setting for Resectable Stages II and III Low Rectal Cancer. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-469603
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Smith, Jessica A.…[et al.]. Clinicopathologic Comparison of High-Dose-Rate Endorectal Brachytherapy versus Conventional Chemoradiotherapy in the Neoadjuvant Setting for Resectable Stages II and III Low Rectal Cancer. International Journal of Surgical Oncology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-469603
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Smith, Jessica A.& Wild, Aaron T.& Singhi, Aatur& Raman, Siva P.& Qiu, Haoming& Kumar, Rachit…[et al.]. Clinicopathologic Comparison of High-Dose-Rate Endorectal Brachytherapy versus Conventional Chemoradiotherapy in the Neoadjuvant Setting for Resectable Stages II and III Low Rectal Cancer. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-469603
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469603
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر