Topical Delivery of Aceclofenac : Challenges and Promises of Novel Drug Delivery Systems
المؤلفون المشاركون
Raza, Kaisar
Malik, Ruchi
Sharma, Gajanand
Katare, O. P.
Kumar, Pramod
Kaur, Manmeet
Kumar, Manish
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Osteoarthritis (OA), a common musculoskeletal disorder, is projected to affect about 60 million people of total world population by 2020.
The associated pain and disability impair the quality of life and also pose economic burden to the patient.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed in OA, while diclofenac is the most prescribed one.
Oral NSAIDs are not very patient friendly, as they cause various gastrointestinal adverse effects like bleeding, ulceration, and perforation.
To enhance the tolerability of diclofenac and decrease the common side effects, aceclofenac (ACE) was developed by its chemical modification.
As expected, ACE is more well-tolerated than diclofenac and possesses superior efficacy but is not completely devoid of the NSAID-tagged side effects.
A series of chemical modifications of already planned drug is unjustified as it consumes quanta of time, efforts, and money, and this approach will also pose stringent regulatory challenges.
Therefore, it is justified to deliver ACE employing tools of drug delivery and nanotechnology to refine its safety profile.
The present review highlights the constraints related to the topical delivery of ACE and the various attempts made so far for the safe and effective topical delivery employing the novel materials and methods.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Raza, Kaisar& Kumar, Manish& Kumar, Pramod& Malik, Ruchi& Sharma, Gajanand& Kaur, Manmeet…[et al.]. 2014. Topical Delivery of Aceclofenac : Challenges and Promises of Novel Drug Delivery Systems. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-469609
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Raza, Kaisar…[et al.]. Topical Delivery of Aceclofenac : Challenges and Promises of Novel Drug Delivery Systems. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-469609
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Raza, Kaisar& Kumar, Manish& Kumar, Pramod& Malik, Ruchi& Sharma, Gajanand& Kaur, Manmeet…[et al.]. Topical Delivery of Aceclofenac : Challenges and Promises of Novel Drug Delivery Systems. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-469609
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469609
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر