CCAATEnhancer-Binding Protein α Is a Crucial Regulator of Human Fat Mass and Obesity Associated Gene Transcription and Expression
المؤلفون المشاركون
Ding, Ying
Ren, Wei
Lu, Jun
Jia, Weiping
Liang, Xiubin
Jiang, Feng
Li, Aimei
Guo, Jianjin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Several susceptibility loci have been reported associated with obesity and T2DM in GWAS.
Fat mass and obesity associated gene (FTO) is the first gene associated with body mass index (BMI) and risk for diabetes in diverse patient populations.
FTO is highly expressed in the brain and pancreas, and is involved in regulating dietary intake and energy expenditure.
While much is known about the epigenetic mutations contributing to obesity and T2DM, less is certain with the expression regulation of FTO gene.
In this study, a highly conserved canonical C/EBPα binding site was located around position −45~−54 bp relative to the human FTO gene transcriptional start site.
Site-directed mutagenesis of the putative C/EBPα binding sites decreased FTO promoter activity.
Overexpression and RNAi studies also indicated that C/EBPα was required for the expression of FTO.
Chromatin immunoprecipitation (ChIP) experiment was carried out and the result shows direct binding of C/EBPα to the putative binding regions in the FTO promoter.
Collectively, our data suggest that C/EBPα may act as a positive regulator binding to FTO promoter and consequently, activates the gene transcription.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ren, Wei& Guo, Jianjin& Jiang, Feng& Lu, Jun& Ding, Ying& Li, Aimei…[et al.]. 2014. CCAATEnhancer-Binding Protein α Is a Crucial Regulator of Human Fat Mass and Obesity Associated Gene Transcription and Expression. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-469632
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ren, Wei…[et al.]. CCAATEnhancer-Binding Protein α Is a Crucial Regulator of Human Fat Mass and Obesity Associated Gene Transcription and Expression. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-469632
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ren, Wei& Guo, Jianjin& Jiang, Feng& Lu, Jun& Ding, Ying& Li, Aimei…[et al.]. CCAATEnhancer-Binding Protein α Is a Crucial Regulator of Human Fat Mass and Obesity Associated Gene Transcription and Expression. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-469632
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469632
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر