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Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease
المؤلفون المشاركون
Wang, XiaoPing
Ascheman, Dana P.
Shi, YongHong
Chen, Juan
Huang, Heqing
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
Interstitial lung disease (ILD) is a common extra-articular manifestation of rheumatoid arthritis (RA) and a significant cause of morbidity and mortality.
The objective of this study was to define high-resolution chest CT (HRCT) and pulmonary function test (PFT) abnormalities capable of identifying asymptomatic, preclinical forms of RA-ILD that may represent precursors to more severe fibrotic lung disease.
Methods.
We analyzed chest HRCTs in consecutively enrolled RA patients and subsequently classified these individuals as RA-ILD or RA-no ILD based on the presence/absence of ground glass opacification, septal thickening, reticulation, traction bronchiectasis, and/or honeycombing.
Coexisting PFT abnormalities (reductions in percent predicted FEV1, FVC, TLC, and/or DLCO) were also used to further characterize occult respiratory defects.
Results.
61% (63/103) of RA patients were classified as RA-ILD based on HRCT and PFT abnormalities, while 39% (40/103) were designated as RA-no ILD.
57/63 RA-ILD patients lacked symptoms of significant dyspnea or cough at the time of HRCT and PFT assessment.
Compared with RA-no ILD, RA-ILD patients were older and had longer disease duration, higher articular disease activity, and more significant PFT abnormalities.
Conclusion.
HRCT represents an effective tool to detect occult/asymptomatic ILD that is highly prevalent in our unselected, university-based cohort of RA patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Juan& Shi, YongHong& Wang, XiaoPing& Huang, Heqing& Ascheman, Dana P.. 2013. Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-469636
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Juan…[et al.]. Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease. Clinical and Developmental Immunology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-469636
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Juan& Shi, YongHong& Wang, XiaoPing& Huang, Heqing& Ascheman, Dana P.. Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-469636
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469636
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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