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Leptomeningeal Cells Transduce Peripheral Macrophages Inflammatory Signal to Microglia in Reponse to Porphyromonas gingivalis LPS
المؤلفون المشاركون
Zhou, Yanmin
Yu, Weixian
Ni, Junjun
Liu, Yicong
Zhang, Xinwen
Nakanishi, Hiroshi
Wu, Zhou
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We report here that the leptomeningeal cells transduce inflammatory signals from peripheral macrophages to brain-resident microglia in response to Porphyromonas gingivalis (P.g.) LPS.
The expression of Toll-like receptor 2 (TLR2), TLR4, TNF-α, and inducible NO synthase was mainly detected in the gingival macrophages of chronic periodontitis patients.
In in vitro studies, P.g.
LPS induced the secretion of TNF-α and IL-1β from THP-1 human monocyte-like cell line and RAW264.7 mouse macrophages.
Surprisingly, the mean mRNA levels of TNF-α and IL-1β in leptomeningeal cells after treatment with the conditioned medium from P.g.
LPS-stimulated RAW264.7 macrophages were significantly higher than those after treatment with P.g.
LPS alone.
Furthermore, the mean mRNA levels of TNF-α and IL-1β in microglia after treatment with the conditioned medium from P.g.
LPS-stimulated leptomeningeal cells were significantly higher than those after P.g.
LPS alone.
These observations suggest that leptomeninges serve as an important route for transducing inflammatory signals from macrophages to microglia by secretion of proinflammatory mediators during chronic periodontitis.
Moreover, propolis significantly reduced the P.g.
LPS-induced TNF-α and IL-1 β production by leptomeningeal cells through inhibiting the nuclear factor-κB signaling pathway.
Together with the inhibitory effect on microglial activation, propolis may be beneficial in preventing neuroinflammation during chronic periodontitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yicong& Wu, Zhou& Zhang, Xinwen& Ni, Junjun& Yu, Weixian& Zhou, Yanmin…[et al.]. 2013. Leptomeningeal Cells Transduce Peripheral Macrophages Inflammatory Signal to Microglia in Reponse to Porphyromonas gingivalis LPS. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-469701
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yicong…[et al.]. Leptomeningeal Cells Transduce Peripheral Macrophages Inflammatory Signal to Microglia in Reponse to Porphyromonas gingivalis LPS. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-469701
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yicong& Wu, Zhou& Zhang, Xinwen& Ni, Junjun& Yu, Weixian& Zhou, Yanmin…[et al.]. Leptomeningeal Cells Transduce Peripheral Macrophages Inflammatory Signal to Microglia in Reponse to Porphyromonas gingivalis LPS. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-469701
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469701
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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