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Dose-Dependent Change in Elimination Kinetics of Ethanol due to Shift of Dominant Metabolizing Enzyme from ADH 1 (Class I) to ADH 3 (Class III) in Mouse
المؤلفون المشاركون
Ohno, Youkichi
Kameyama, Kouji
Haseba, Takeshi
Mashimo, Keiko
المصدر
International Journal of Hepatology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
ADH 1 and ADH 3 are major two ADH isozymes in the liver, which participate in systemic alcohol metabolism, mainly distributing in parenchymal and in sinusoidal endothelial cells of the liver, respectively.
We investigated how these two ADHs contribute to the elimination kinetics of blood ethanol by administering ethanol to mice at various doses, and by measuring liver ADH activity and liver contents of both ADHs.
The normalized AUC (AUC/dose) showed a concave increase with an increase in ethanol dose, inversely correlating with β.
CLT (dose/AUC) linearly correlated with liver ADH activity and also with both the ADH-1 and -3 contents (mg/kg B.W.).
When ADH-1 activity was calculated by multiplying ADH-1 content by its Vmax/mg (4.0) and normalized by the ratio of liver ADH activity of each ethanol dose to that of the control, the theoretical ADH-1 activity decreased dose-dependently, correlating with β.
On the other hand, the theoretical ADH-3 activity, which was calculated by subtracting ADH-1 activity from liver ADH activity and normalized, increased dose-dependently, correlating with the normalized AUC.
These results suggested that the elimination kinetics of blood ethanol in mice was dose-dependently changed, accompanied by a shift of the dominant metabolizing enzyme from ADH 1 to ADH 3.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Haseba, Takeshi& Kameyama, Kouji& Mashimo, Keiko& Ohno, Youkichi. 2011. Dose-Dependent Change in Elimination Kinetics of Ethanol due to Shift of Dominant Metabolizing Enzyme from ADH 1 (Class I) to ADH 3 (Class III) in Mouse. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-469771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Haseba, Takeshi…[et al.]. Dose-Dependent Change in Elimination Kinetics of Ethanol due to Shift of Dominant Metabolizing Enzyme from ADH 1 (Class I) to ADH 3 (Class III) in Mouse. International Journal of Hepatology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-469771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Haseba, Takeshi& Kameyama, Kouji& Mashimo, Keiko& Ohno, Youkichi. Dose-Dependent Change in Elimination Kinetics of Ethanol due to Shift of Dominant Metabolizing Enzyme from ADH 1 (Class I) to ADH 3 (Class III) in Mouse. International Journal of Hepatology. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-469771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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