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Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis : New Therapeutic Approaches for Bisphosphonates
المؤلفون المشاركون
Baroja-Mazo, Alberto
Pelegrín, Pablo
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
P2X7 receptor-mediated purinergic signaling is a well-known mechanism involved in bone remodeling.
The P2X7 receptor has been implicated in the pathophysiology of various bone and cartilage diseases, including rheumatoid arthritis (RA), a widespread and complex chronic inflammatory disorder.
The P2X7 receptor induces the release into the synovial fluid of the proinflammatory factors (e.g., interleukin-1β, prostaglandins, and proteases) responsible for the clinical symptoms of RA.
Thus, the P2X7 receptor is emerging as a novel anti-inflammatory therapeutic target, and various selective P2X7 receptor antagonists are under clinical trials.
Extracellular ATP signaling acting through the P2X7 receptor is a complex and dynamic scenario, which varies over the course of inflammation.
This signaling is partially modulated by the activity of ectonucleotidases, which degrade extracellular ATP to generate other active molecules such as adenosine or pyrophosphates.
Recent evidence suggests differential extracellular metabolism of ATP during the resolution of inflammation to generate pyrophosphates.
Extracellular pyrophosphate dampens proinflammatory signaling by promoting alternative macrophage activation.
Our paper shows that bisphosphonates are metabolically stable pyrophosphate analogues that are able to mimic the anti-inflammatory function of pyrophosphates.
Bisphosphonates are arising per se as promising anti-inflammatory drugs to treat RA, and this therapy could be improved when administrated in combination with P2X7 receptor antagonists.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Baroja-Mazo, Alberto& Pelegrín, Pablo. 2012. Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis : New Therapeutic Approaches for Bisphosphonates. Journal of Osteoporosis،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-469775
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Baroja-Mazo, Alberto& Pelegrín, Pablo. Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis : New Therapeutic Approaches for Bisphosphonates. Journal of Osteoporosis No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-469775
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Baroja-Mazo, Alberto& Pelegrín, Pablo. Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis : New Therapeutic Approaches for Bisphosphonates. Journal of Osteoporosis. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-469775
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469775
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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