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Maternal Baicalin Treatment Increases Fetal Lung Surfactant Phospholipids in Rats
المؤلفون المشاركون
Wang, Leng-Fang
Chen, Chung-Ming
Cheng, Kur-Ta
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-04
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Baicalin is a flavonoid compound purified from the medicinal plant Scutellaria baicalensis Georgi and has been reported to stimulate surfactant protein (SP)-A gene expression in human lung epithelial cell lines (H441).
The aims of this study were to determine whether maternal baicalin treatment could increase lung surfactant production and induce lung maturation in fetal rats.
This study was performed with timed pregnant Sprague-Dawley rats.
One-day baicalin group mothers were injected intraperitoneally with baicalin (5 mg/kg/day) on Day 18 of gestation.
Two-day baicalin group mothers were injected intraperitoneally with baicalin (5 mg/kg/day) on Days 17 and 18 of gestation.
Control group mothers were injected with vehicle alone on Day 18 of gestation.
On Day 19 of gestation, fetuses were delivered by cesarean section.
Maternal treatment with 2-day baicalin significantly increased saturated phospholipid when compared with control group and total phospholipid in fetal lung tissue when compared with control and 1-day baicalin groups.
Antenatal treatment with 2-day baicalin significantly increased maternal growth hormone when compared with control group.
Fetal lung SP-A mRNA expression and maternal serum corticosterone levels were comparable among the three experimental groups.
Maternal baicalin treatment increases pulmonary surfactant phospholipids of fetal rat lungs and the improvement was associated with increased maternal serum growth hormone.
These results suggest that antenatal baicalin treatment might accelerate fetal rat lung maturation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Chung-Ming& Wang, Leng-Fang& Cheng, Kur-Ta. 2011. Maternal Baicalin Treatment Increases Fetal Lung Surfactant Phospholipids in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-469825
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Chung-Ming…[et al.]. Maternal Baicalin Treatment Increases Fetal Lung Surfactant Phospholipids in Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-469825
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Chung-Ming& Wang, Leng-Fang& Cheng, Kur-Ta. Maternal Baicalin Treatment Increases Fetal Lung Surfactant Phospholipids in Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-469825
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469825
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