A Framework to Examine the Role of Epigenetics in Health Disparities among Native Americans
المؤلفون المشاركون
Gill, Jessica
Brockie, Teresa N.
Heinzelmann, Morgan
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Native Americans disproportionately experience adverse childhood experiences (ACEs) as well as health disparities, including high rates of posttraumatic stress, depression, and substance abuse.
Many ACEs have been linked to methylation changes in genes that regulate the stress response, suggesting that these molecular changes may underlie the risk for psychiatric disorders related to ACEs.
Methods.
We reviewed published studies to provide evidence that ACE-related methylation changes contribute to health disparities in Native Americans.
This framework may be adapted to understand how ACEs may result in health disparities in other racial/ethnic groups.
Findings.
Here we provide evidence that links ACEs to methylation differences in genes that regulate the stress response.
Psychiatric disorders are also associated with methylation differences in endocrine, immune, and neurotransmitter genes that serve to regulate the stress response and are linked to psychiatric symptoms and medical morbidity.
We provide evidence linking ACEs to these epigenetic modifications, suggesting that ACEs contribute to the vulnerability for developing psychiatric disorders in Native Americans.
Conclusion.
Additional studies are needed to better understand how ACEs contribute to health and well-being.
These studies may inform future interventions to address these serious risks and promote the health and well-being of Native Americans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brockie, Teresa N.& Heinzelmann, Morgan& Gill, Jessica. 2013. A Framework to Examine the Role of Epigenetics in Health Disparities among Native Americans. Nursing Research and Practice،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-469953
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brockie, Teresa N.…[et al.]. A Framework to Examine the Role of Epigenetics in Health Disparities among Native Americans. Nursing Research and Practice No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-469953
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brockie, Teresa N.& Heinzelmann, Morgan& Gill, Jessica. A Framework to Examine the Role of Epigenetics in Health Disparities among Native Americans. Nursing Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-469953
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-469953
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر