Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction

الملخص EN

Valproic acid-induced hyperammonemic encephalopathy is a rare yet serious adverse drug reaction.

Medication interactions such a valproic acid and topiramate can precipitate an event.

We present the case of a 52-year-old female that presented with acute mental status change and hypersomnolence due to hyperammonemia caused by a valproic acid derivative.

The patient improved after withdrawal of the offending medications and treatment with lactulose.

Clinicians should remain hypervigilant in monitoring for valproic acid-induced hyperammonemic encephalopathy and risk factors such as polypharmacy.