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Identification of Sphingomyelinase on the Surface of Chlamydia pneumoniae : Possible Role in the Entry into Its Host Cells
المؤلفون المشاركون
Peñate Medina, Oula
Peñate Medina, Tuula A.
Lahesmaa, Riitta
Korhonen, Juha T.
Kinnunen, Paavo K. J.
Puolakkainen, Mirja
المصدر
Interdisciplinary Perspectives on Infectious Diseases
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-13
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
We have recently suggested a novel mechanism, autoendocytosis, for the entry of certain microbes into their hosts, with a key role played by the sphingomyelinase-catalyzed topical conversion of sphingomyelin to ceramide, the differences in the biophysical properties of these two lipids providing the driving force.
The only requirement for such microbes to utilize this mechanism is that they should have a catalytically active SMase on their outer surface while the target cells should expose sphingomyelin in the external leaflet of their plasma membrane.
In pursuit of possible microbial candidates, which could utilize this putative mechanism, we conducted a sequence similarity search for SMase.
Because of the intriguing cellular and biochemical characteristics of the poorly understood entry of Chlamydia into its host cells these microbes were of particular interest.
SMase activity was measured in vitro from isolated C.
pneumoniae elementary bodies (EB) and in the lysate from E.
coli cells transfected with a plasmid expressing CPn0300 protein having sequence similarity to SMase.
Finally, pretreatment of host cells with exogenous SMase resulting in loss plasma membrane sphingomyelin attenuated attachment of EB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peñate Medina, Tuula A.& Korhonen, Juha T.& Lahesmaa, Riitta& Puolakkainen, Mirja& Peñate Medina, Oula& Kinnunen, Paavo K. J.. 2014. Identification of Sphingomyelinase on the Surface of Chlamydia pneumoniae : Possible Role in the Entry into Its Host Cells. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-470110
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peñate Medina, Tuula A.…[et al.]. Identification of Sphingomyelinase on the Surface of Chlamydia pneumoniae : Possible Role in the Entry into Its Host Cells. Interdisciplinary Perspectives on Infectious Diseases No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-470110
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peñate Medina, Tuula A.& Korhonen, Juha T.& Lahesmaa, Riitta& Puolakkainen, Mirja& Peñate Medina, Oula& Kinnunen, Paavo K. J.. Identification of Sphingomyelinase on the Surface of Chlamydia pneumoniae : Possible Role in the Entry into Its Host Cells. Interdisciplinary Perspectives on Infectious Diseases. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-470110
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470110
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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