Incidence and Pattern of Graft-versus-Host Disease in Patients Undergoing Allogeneic Transplantation after Nonmyeloablative Conditioning with Total Lymphoid Irradiation and Antithymocyte Globulin
المؤلفون المشاركون
Leadmon, Sonia
Cumpston, Aaron
Veltri, Lauren
Tse, William
Regier, Michael
Craig, Michael
Hamadani, Mehdi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Nonmyeloablative (NMA) conditioning with total lymphoid irradiation and antithymocyte globulin (TLI/ATG) has been shown to protect against acute graft-versus-host disease (GVHD).
We report here our institutional experience with allogeneic transplantation following NMA conditioning with TLI/ATG (n=21).
GVHD prophylaxis consisted of a combination of a calcineurin inhibitor and mycophenolate mofetil.
Median patient age was 59 years.
The median followup of surviving patients is 545 days.
One patient experienced primary graft rejection.
The median time to neutrophil engraftment was 18 days and platelet engraftment was 9.5 days.
The cumulative incidence (CI) of grade II–IV acute GVHD at day +100 was 28.6% and 38.1% at day +180.
The CI for grade III-IV acute GVHD was 28.6% at day +180.
CI of chronic GVHD was 45.2% at 1 year.
The CI of disease relapse was 9.5% at 1 year.
The rate of nonrelapse mortality (NRM) was 0% at day +100 and only 9.5% at 1 year.
The overall and progression free survival at 1 year was 81% and 80.4%, respectively.
Our limited, retrospective data show encouraging relapse and NRM rates with TLI/ATG-based NMA conditioning, but with higher than previously reported rates of acute and chronic GVHD, underscoring the need for novel strategies designed to effectively prevent GVHD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Veltri, Lauren& Regier, Michael& Cumpston, Aaron& Leadmon, Sonia& Tse, William& Craig, Michael…[et al.]. 2013. Incidence and Pattern of Graft-versus-Host Disease in Patients Undergoing Allogeneic Transplantation after Nonmyeloablative Conditioning with Total Lymphoid Irradiation and Antithymocyte Globulin. Bone Marrow Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470304
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Veltri, Lauren…[et al.]. Incidence and Pattern of Graft-versus-Host Disease in Patients Undergoing Allogeneic Transplantation after Nonmyeloablative Conditioning with Total Lymphoid Irradiation and Antithymocyte Globulin. Bone Marrow Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-470304
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Veltri, Lauren& Regier, Michael& Cumpston, Aaron& Leadmon, Sonia& Tse, William& Craig, Michael…[et al.]. Incidence and Pattern of Graft-versus-Host Disease in Patients Undergoing Allogeneic Transplantation after Nonmyeloablative Conditioning with Total Lymphoid Irradiation and Antithymocyte Globulin. Bone Marrow Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470304
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470304
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر