Quantitative Assessment of 99mTc-Depreotide Uptake in Oesophageal Cancer and Precursor Conditions and Its Reflection in Immunohistochemically Detected Somatostatin Receptors
المؤلفون المشاركون
Svensson, Leif
Herlin, Gunnar
Aspelin, Peter
Axelsson, Rimma
Öst, Åke
Lundell, Lars
المصدر
Radiology Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Somatostatin receptors (SSTRs) are over-expressed in several tumors making it possible for imaging with labelled SSTR.
A previous study showed feasibility to image oesophageal cancer with SSTR analogue 99mTc-depreotide.
Purpose.
(1) To investigate expression of the SSTRs in different types of esophageal carcinoma and (2) to correlate such an expression with 99mTc-depreotide uptake in these lesions.
Material and Methods.
Total 28 patients (17 with esophageal cancer and 11 with Barrett’s esophagus) were examined with 99mTc-depreotide scintigraphy.
The SSTR2A, SSTR2B, SSTR3, and SSTR5 were analyzed immunohistochemically in the lesion samples.
Results.
Among the patients with adenocarcinoma 10/11 expressed different amounts of SSTRs, while SSTRs were absent in 5/6 patients with Squamous cell carcinoma (Sqcc).
There was no correlation neither between the 99mTc-depreotide uptake and the amount of SSTRs nor between the amount of SSTRs and differentiation grade of the tumor.
Conclusions.
(1) SSTRs are expressed in esophageal carcinoma and more abundantly so in adenocancer specimens; (2) in vivo 99mTc-depreotide uptake does not obviously correlate with the immunohistochemically detection of SSTRs of different subtypes in esophageal carcinoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Herlin, Gunnar& Lundell, Lars& Öst, Åke& Aspelin, Peter& Svensson, Leif& Axelsson, Rimma. 2012. Quantitative Assessment of 99mTc-Depreotide Uptake in Oesophageal Cancer and Precursor Conditions and Its Reflection in Immunohistochemically Detected Somatostatin Receptors. Radiology Research and Practice،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-470356
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Herlin, Gunnar…[et al.]. Quantitative Assessment of 99mTc-Depreotide Uptake in Oesophageal Cancer and Precursor Conditions and Its Reflection in Immunohistochemically Detected Somatostatin Receptors. Radiology Research and Practice No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-470356
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Herlin, Gunnar& Lundell, Lars& Öst, Åke& Aspelin, Peter& Svensson, Leif& Axelsson, Rimma. Quantitative Assessment of 99mTc-Depreotide Uptake in Oesophageal Cancer and Precursor Conditions and Its Reflection in Immunohistochemically Detected Somatostatin Receptors. Radiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-470356
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470356
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر