Evaluation of Autogenous Engineered Septal Cartilage Grafts in Rabbits : A Minimally Invasive Preclinical Model
المؤلفون المشاركون
Neuman, Monica
Reuther, Marsha
Lin, Victor
Kushnaryov, Anton
Sah, Robert L.
Watson, Deborah
Briggs, Kristen K.
Yamaguchi, Tomonoro
Wong, Van W.
Masuda, Koichi
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
(1) Evaluate safety of autogenous engineered septal neocartilage grafts and (2) compare properties of implanted grafts versus controls.
Study Design.
Prospective, basic science.
Setting.
Research laboratory.
Methods.
Constructs were fabricated from septal cartilage and then cultured in vitro or implanted on the nasal dorsum as autogenous grafts for 30 or 60 days.
Rabbits were monitored for local and systemic complications.
Histological, biochemical, and biomechanical properties of constructs were evaluated.
Results.
No serious complications were observed.
Implanted constructs contained more DNA (P<0.01) and less sGAG perDNA (P<0.05) when compared with in vitro controls.
Confined compressive aggregate moduli were also higher in implanted constructs (P<0.05) and increased with longer in vivo incubation time (P<0.01).
Implanted constructs displayed resorption rates of 20–45 percent.
Calcium deposition in implanted constructs was observe.
Conclusion.
Autogenous engineered septal cartilage grafts were well tolerated.
As seen in experiments with athymic mice, implanted constructs accumulated more DNA and less sGAG when compared with in vitro controls.
Confined compressive aggregate moduli were higher in implanted constructs.
Implanted constructs displayed resorption rates similar to previously published studies using autogenous implants of native cartilage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kushnaryov, Anton& Yamaguchi, Tomonoro& Briggs, Kristen K.& Wong, Van W.& Reuther, Marsha& Neuman, Monica…[et al.]. 2014. Evaluation of Autogenous Engineered Septal Cartilage Grafts in Rabbits : A Minimally Invasive Preclinical Model. Advances in Otolaryngology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-470388
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kushnaryov, Anton…[et al.]. Evaluation of Autogenous Engineered Septal Cartilage Grafts in Rabbits : A Minimally Invasive Preclinical Model. Advances in Otolaryngology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-470388
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kushnaryov, Anton& Yamaguchi, Tomonoro& Briggs, Kristen K.& Wong, Van W.& Reuther, Marsha& Neuman, Monica…[et al.]. Evaluation of Autogenous Engineered Septal Cartilage Grafts in Rabbits : A Minimally Invasive Preclinical Model. Advances in Otolaryngology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-470388
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470388
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر