![](/images/graphics-bg.png)
Overexpression of S6 Kinase 1 in Brain Tumours Is Associated with Induction of Hypoxia-Responsive Genes and Predicts Patients' Survival
المؤلف
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
mTOR/S6K pathway is a crucial regulator of cell growth and metabolism.
Deregulated signalling via S6K has been linked to various human pathologies, including metabolic disorders and cancer.
Many of the molecules signalling upstream of S6K have been shown to be either mutated or overexpressed in tumours, leading to S6K activation.
The role of S6K1 in brain tumours is not fully investigated.
In this study, we investigated the gene expression profile of S6 kinases in brain and CNS tumours using the publically available Cancer Microarray Database.
We found that S6K1 but not S6K2 gene is overexpressed in brain tumours and this upregulation is associated with patients’ poor survival.
Furthermore, we interrogated Oncomine database for the expression profile of hypoxia-induced genes using a literature-defined concept.
This gene list included HIF1A, VEGFA, SOX4, SOX9, MMP2, and NEDD9.
We show that those genes are upregulated in all brain tumour studies investigated.
Additionally, we analysed the coexpression profile of S6K1 and hypoxia responsive genes.
The analysis was done across 4 different brain studies and showed that S6K1 is co-overexpressed with several hypoxia responsive genes.
This study highlights the possible role of S6K1 in brain tumour progression and prediction of patients’ survival.
However, new epidemiological studies should be conducted in order to confirm these associations and to refine the role of S6K1 in brain tumours as a useful marker for patients’ survival.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ismail, Heba M. S.. 2012. Overexpression of S6 Kinase 1 in Brain Tumours Is Associated with Induction of Hypoxia-Responsive Genes and Predicts Patients' Survival. Journal of Oncology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-470492
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ismail, Heba M. S.. Overexpression of S6 Kinase 1 in Brain Tumours Is Associated with Induction of Hypoxia-Responsive Genes and Predicts Patients' Survival. Journal of Oncology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-470492
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ismail, Heba M. S.. Overexpression of S6 Kinase 1 in Brain Tumours Is Associated with Induction of Hypoxia-Responsive Genes and Predicts Patients' Survival. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-470492
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470492
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)