Value and Limits of Routine Histology Alone or Combined with Glutamine Synthetase Immunostaining in the Diagnosis of Hepatocellular Adenoma Subtypes on Surgical Specimens
المؤلفون المشاركون
Bioulac-Sage, Paulette
Le Bail, Brigitte
Balabaud, Charles
Taouji, Saïd
Possenti, Laurent
المصدر
International Journal of Hepatology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Immunohistochemistry is a valid method to classify hepatocellular adenoma (HCA).
The aim was to test the performance of routine histology combined to glutamine synthetase (GS) staining to identify the 2 major HCA subtypes: HNF1α inactivated (H-HCA) and inflammatory HCA (IHCA).
114 surgical cases, previously classified by immunohistochemistry, were analysed.
Group A comprised 45 H-HCAs, 44 IHCAs, and 9 β-catenin-activated IHCAs (b-IHCA), and group B, 16 b-HCA and unclassified HCA (UHCA).
Steatosis was the hallmark of H-HCA.
IHCA and b-IHCA were mainly characterized by inflammation, thick arteries, and sinusoidal dilatation; b-IHCA could not be differentiated from IHCA by routine histology.
Group B was identified by default.
A control set (91 cases) was analyzed using routine and GS stainings (without knowing immunohistochemical results).
Among the 45 H-HCAs and 27 IHCAs, 40 and 24 were correctly classified, respectively.
Among the 10 b-IHCAs, 4 were identified as such using additional GS.
Eight of the 9 HCAs that were neither H-HCA nor IHCA were correctly classified.
Conclusion.
Routine histology allows to diagnose >85% of the 2 major HCA subtypes.
GS is essential to identify b-HCA.
This study demonstrates that a “palliative” diagnostic approach can be proposed, when the panel of specific antibodies is not available.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bioulac-Sage, Paulette& Taouji, Saïd& Le Bail, Brigitte& Possenti, Laurent& Balabaud, Charles. 2013. Value and Limits of Routine Histology Alone or Combined with Glutamine Synthetase Immunostaining in the Diagnosis of Hepatocellular Adenoma Subtypes on Surgical Specimens. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470534
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bioulac-Sage, Paulette…[et al.]. Value and Limits of Routine Histology Alone or Combined with Glutamine Synthetase Immunostaining in the Diagnosis of Hepatocellular Adenoma Subtypes on Surgical Specimens. International Journal of Hepatology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-470534
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bioulac-Sage, Paulette& Taouji, Saïd& Le Bail, Brigitte& Possenti, Laurent& Balabaud, Charles. Value and Limits of Routine Histology Alone or Combined with Glutamine Synthetase Immunostaining in the Diagnosis of Hepatocellular Adenoma Subtypes on Surgical Specimens. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470534
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470534
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر