The Role of Nephritis-Associated Plasmin Receptor (NAPlr)‎ in Glomerulonephritis Associated with Streptococcal Infection

المؤلفون المشاركون

Kumagai, Hiroo
Yamakami, Kazuo
Takechi, Hanako
Oshima, Naoki
Oda, Takashi
Sakurai, Yutaka
Yamamoto, Kojiro
Yoshizawa, Nobuyuki

المصدر

Journal of Biomedicine and Biotechnology

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-10-14

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

It is well known that glomerulonephritis can occur after streptococcal infection, which is classically referred to as acute poststreptococcal glomerulonephritis (APSGN).

The pathogenic mechanism of APSGN has been described by so-called immune complex theory, which involves glomerular deposition of nephritogenic streptococcal antigen and subsequent formation of immune complexes in situ and/or the deposition of circulating antigen-antibody complexes.

However, the exact entity of the causative antigen has remained a matter of debate.

We isolated a nephritogenic antigen for APSGN from the cytoplasmic fractions of group A streptococcus (GAS) depending on the affinity for IgG of APSGN patients.

The amino acid and the nucleotide sequences of the isolated protein revealed to be highly identical to those of reported plasmin(ogen) receptor of GAS.

Thus, we termed this antigen nephritis-associated plasmin receptor (NAPlr).

Immunofluorescence staining of the renal biopsy tissues with anti-NAPlr antibody revealed glomerular NAPlr deposition in essentially all patients with early-phase APSGN.

Furthermore, glomerular plasmin activity was detected by in situ zymography in the distribution almost identical to NAPlr deposition in renal biopsy tissues of APSGN patients.

These data suggest that NAPlr has a direct, nonimmunologic function as a plasmin receptor and may contribute to the pathogenesis of APSGN by maintaining plasmin activity.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Oda, Takashi& Yoshizawa, Nobuyuki& Yamakami, Kazuo& Sakurai, Yutaka& Takechi, Hanako& Yamamoto, Kojiro…[et al.]. 2012. The Role of Nephritis-Associated Plasmin Receptor (NAPlr) in Glomerulonephritis Associated with Streptococcal Infection. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-470565

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Oda, Takashi…[et al.]. The Role of Nephritis-Associated Plasmin Receptor (NAPlr) in Glomerulonephritis Associated with Streptococcal Infection. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-470565

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Oda, Takashi& Yoshizawa, Nobuyuki& Yamakami, Kazuo& Sakurai, Yutaka& Takechi, Hanako& Yamamoto, Kojiro…[et al.]. The Role of Nephritis-Associated Plasmin Receptor (NAPlr) in Glomerulonephritis Associated with Streptococcal Infection. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-470565

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-470565