Symptomatic Histologically Proven Necrosis of Brain following Stereotactic Radiation and Ipilimumab in Six Lesions in Four Melanoma Patients
المؤلفون المشاركون
Hong, Angela
Neyns, Bart
Okera, Meena
Shivalingam, Brindha
Chan, Matthew
Michotte, Alex
Kefford, Richard
Feng, Linda
Duerinck, Johnny
Du Four, Stephanie
Fogarty, Gerald
Charakidis, Michail
Wilgenhof, Sofie
Wang, Wei
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-01
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Four cases previously treated with ipilimumab with a total of six histologically confirmed symptomatic lesions of RNB without any sign of active tumour following stereotactic irradiation of MBM are reported.
These lesions were all originally thought to be disease recurrence.
In two cases, ipilimumab was given prior to SRT; in the other two ipilimumab was given after SRT.
The average time from first ipilimumab to RNB was 15 months.
The average time from SRT to RNB was 11 months.
The average time from first diagnosis of MBM to last follow-up was 20 months at which time three patients were still alive, one with no evidence of disease.
These cases represent approximately three percent of the total cases of melanoma and ten percent of those cases treated with ipilimumab irradiated in our respective centres collectively.
We report this to highlight this new problem so that others may have a high index of suspicion, allowing, if clinically warranted, aggressive surgical salvage, possibly resulting in increased survival.
Further studies prospectively collecting data to understand the denominator of this problem are needed to determine whether this problem is just the result of longer survival or whether there is some synergy between these two modalities that are increasingly being used together.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Du Four, Stephanie& Hong, Angela& Chan, Matthew& Charakidis, Michail& Duerinck, Johnny& Wilgenhof, Sofie…[et al.]. 2014. Symptomatic Histologically Proven Necrosis of Brain following Stereotactic Radiation and Ipilimumab in Six Lesions in Four Melanoma Patients. Case Reports in Oncological Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470583
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Du Four, Stephanie…[et al.]. Symptomatic Histologically Proven Necrosis of Brain following Stereotactic Radiation and Ipilimumab in Six Lesions in Four Melanoma Patients. Case Reports in Oncological Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-470583
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Du Four, Stephanie& Hong, Angela& Chan, Matthew& Charakidis, Michail& Duerinck, Johnny& Wilgenhof, Sofie…[et al.]. Symptomatic Histologically Proven Necrosis of Brain following Stereotactic Radiation and Ipilimumab in Six Lesions in Four Melanoma Patients. Case Reports in Oncological Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470583
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470583
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر