![](/images/graphics-bg.png)
Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer
المؤلفون المشاركون
Yamamoto, Yasuhiro
Mamiya, Noriaki
Yamazaki, Hirotaka
Kamiya, Kazunori
Suzuki, Shigetaka
Chisato, Naoyuki
Kono, Toru
Ebisawa, Yosiaki
Asama, Toshiyuki
Watari, Jiro
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Peripheral neurotoxicity is the major limiting factor for oxaliplatin therapy.
Goshajinkigan (GJG), a traditional Japanese herbal medicine, was recently shown to be effective in protecting against the neurotoxicity of taxanes in Japan.
We retrospectively investigated the effect of GJG on peripheral neurotoxicity associated with oxaliplatin therapy.
Ninety patients with metastatic colorectal cancer that received FOLFOX4 or modified FOLFOX6 therapy were assigned to receive one of the following adjuncts: oral GJG at 7.5 g day−1 (Group A, n=11), intravenous supplementation of calcium gluconate and magnesium sulfate (1 g each before and after FOLFOX) (Group B, n=14), combined GJG and calcium gluconate and magnesium sulfate therapies (Group C, n=21), or no concomitant therapy (Group D, n=44).
The incidence of peripheral neurotoxicity was investigated when the cumulative dose of oxaliplatin exceeded 500 mg m−2.
When the cumulative dose of oxaliplatin exceeded 500 mg m−2, the incidence of neuropathy (all grades) in Groups A–D was 50.0%, 100%, 78.9%, and 91.7%, respectively.
It was lowest in the group that received GJG alone.
Concomitant administration of GJG reduced the neurotoxicity of oxaliplatin in patients that received chemotherapy for colorectal cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kono, Toru& Mamiya, Noriaki& Chisato, Naoyuki& Ebisawa, Yosiaki& Yamazaki, Hirotaka& Watari, Jiro…[et al.]. 2011. Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-470645
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kono, Toru…[et al.]. Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-470645
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kono, Toru& Mamiya, Noriaki& Chisato, Naoyuki& Ebisawa, Yosiaki& Yamazaki, Hirotaka& Watari, Jiro…[et al.]. Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-470645
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470645
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)