Alstonine as an Antipsychotic : Effects on Brain Amines and Metabolic Changes
المؤلفون المشاركون
Okunji, Christopher O.
Piato, Ângelo L.
Flório, Jorge
Linck, Viviane M.
Herrmann, Ana P.
Iwu, Maurice M.
Figueiró, Micheli
Leal, Mirna B.
Elisabetsky, Elaine
Detanico, Bernardo C.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Managing schizophrenia has never been a trivial matter.
Furthermore, while classical antipsychotics induce extrapyramidal side effects and hyperprolactinaemia, atypical antipsychotics lead to diabetes, hyperlipidaemia, and weight gain.
Moreover, even with newer drugs, a sizable proportion of patients do not show significant improvement.
Alstonine is an indole alkaloid identified as the major component of a plant-based remedy used in Nigeria to treat the mentally ill.
Alstonine presents a clear antipsychotic profile in rodents, apparently with differential effects in distinct dopaminergic pathways.
The aim of this study was to complement the antipsychotic profile of alstonine, verifying its effects on brain amines in mouse frontal cortex and striatum.
Additionally, we examined if alstonine induces some hormonal and metabolic changes common to antipsychotics.
HPLC data reveal that alstonine increases serotonergic transmission and increases intraneuronal dopamine catabolism.
In relation to possible side effects, preliminary data suggest that alstonine does not affect prolactin levels, does not induce gains in body weight, but prevents the expected fasting-induced decrease in glucose levels.
Overall, this study reinforces the proposal that alstonine is a potential innovative antipsychotic, and that a comprehensive understanding of its neurochemical basis may open new avenues to developing newer antipsychotic medications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Linck, Viviane M.& Herrmann, Ana P.& Piato, Ângelo L.& Detanico, Bernardo C.& Figueiró, Micheli& Flório, Jorge…[et al.]. 2011. Alstonine as an Antipsychotic : Effects on Brain Amines and Metabolic Changes. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-470655
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Linck, Viviane M.…[et al.]. Alstonine as an Antipsychotic : Effects on Brain Amines and Metabolic Changes. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-470655
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Linck, Viviane M.& Herrmann, Ana P.& Piato, Ângelo L.& Detanico, Bernardo C.& Figueiró, Micheli& Flório, Jorge…[et al.]. Alstonine as an Antipsychotic : Effects on Brain Amines and Metabolic Changes. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-470655
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470655
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر