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Electrochemical Analysis of Antichemotherapeutic Drug Zanosar in Pharmaceutical and Biological Samples by Differential Pulse Polarography
المؤلفون المشاركون
Sreedhar, NeelamYughandhar
Reddy, Chennupalle Nageswara
ReddyPrasad, Puthalapattu
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The electrochemical reduction of zanosar was investigated systematically by direct current polarography, cyclic voltammetry, and differential pulse polarography (DPP).
A simple DPP technique was proposed for the direct quantitative determination of anticancer drug zanosar in pharmaceutical formulation and spiked human urine samples for the first time.
The reduction potential was −0.28 V versus Ag/AgCl with a hanging mercury drop electrode in Britton-Robinson buffer as supporting electrolyte.
The dependence of the intensities of currents and potentials on pH, concentration, scan rate, deposition time, and nature of the supporting electrolyte was investigated.
The calibration curve was found to be linear with the following equation: y=0.4041x+0.012, with a correlation coefficient of 0.992 (R2) over a concentration range from 1.0×10-7 M to 1.0×10-3 M.
In the present investigation, the achieved limit of detection (LOD) and limit of quantization (LQD) were 7.42×10-8 M and 2.47×10-8 M; respectively.
Excipients did not interfere with the determination of zanosar in pharmaceutical formulation and spiked urine samples.
Precision and accuracy of the developed method were checked by recovery studies in pharmaceutical formulation and spiked human urine samples.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Reddy, Chennupalle Nageswara& ReddyPrasad, Puthalapattu& Sreedhar, NeelamYughandhar. 2013. Electrochemical Analysis of Antichemotherapeutic Drug Zanosar in Pharmaceutical and Biological Samples by Differential Pulse Polarography. Journal of Analytical Methods in Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-470853
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Reddy, Chennupalle Nageswara…[et al.]. Electrochemical Analysis of Antichemotherapeutic Drug Zanosar in Pharmaceutical and Biological Samples by Differential Pulse Polarography. Journal of Analytical Methods in Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-470853
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Reddy, Chennupalle Nageswara& ReddyPrasad, Puthalapattu& Sreedhar, NeelamYughandhar. Electrochemical Analysis of Antichemotherapeutic Drug Zanosar in Pharmaceutical and Biological Samples by Differential Pulse Polarography. Journal of Analytical Methods in Chemistry. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-470853
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470853
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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