Immunophenotypes and Immune Markers Associated with Acute Promyelocytic Leukemia Prognosis
المؤلفون المشاركون
Meng, Fan-Yi
Jiang, Ling
Wang, Zhi-Xiang
Xu, Fang
Wang, Chun-Li
Yi, Zheng-Shan
Huang, Kai-Kai
Jiang, Xue-Jie
Yin, Chang-Xin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-19
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
CD2+, CD34+, and CD56+ immunophenotypes are associated with poor prognoses of acute promyelocytic leukemia (APL).
The present study aimed to explore the role of APL immunophenotypes and immune markers as prognostic predictors on clinical outcomes.
A total of 132 patients with de novo APL were retrospectively analyzed.
Immunophenotypes were determined by flow cytometry.
Clinical features, complete remission (CR), relapse, and five-year overall survival (OS) rate were assessed and subjected to multivariate analyses.
The CD13+CD33+HLA-DR-CD34− immunophenotype was commonly observed in patients with APL.
Positive rates for other APL immune markers including cMPO, CD117, CD64, and CD9 were 68.7%, 26%, 78.4%, and 96.6%, respectively.
When compared with patients with CD2− APL, patients with CD2+ APL had a significantly higher incidence of early death (50% versus 15.7%; P=0.016), lower CR rate (50% versus 91.1%; P=0.042), and lower five-year OS rate (41.7% versus 74.2%; P=0.018).
White blood cell (WBC) count before treatment was found to be the only independent risk factor of early death, CR failure, and five-year mortality rate.
Flow cytometric immunophenotype analysis can facilitate prompt APL diagnosis.
Multivariate analysis has demonstrated that WBC count before treatment is the only known independent risk factor that predicts prognosis for APL in this study population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Fang& Yin, Chang-Xin& Wang, Chun-Li& Jiang, Xue-Jie& Jiang, Ling& Wang, Zhi-Xiang…[et al.]. 2014. Immunophenotypes and Immune Markers Associated with Acute Promyelocytic Leukemia Prognosis. Disease Markers،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470969
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Fang…[et al.]. Immunophenotypes and Immune Markers Associated with Acute Promyelocytic Leukemia Prognosis. Disease Markers No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-470969
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Fang& Yin, Chang-Xin& Wang, Chun-Li& Jiang, Xue-Jie& Jiang, Ling& Wang, Zhi-Xiang…[et al.]. Immunophenotypes and Immune Markers Associated with Acute Promyelocytic Leukemia Prognosis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470969
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-470969
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر