Corni Fructus Containing Formulation Attenuates Weight Gain in Mice with Diet-Induced Obesity and Regulates Adipogenesis through AMPK
المؤلفون المشاركون
Jeon, Yong-Deok
Kim, Hye-Lin
Park, Jinbong
Ko, Seong-Gyu
Lim, Hara
Lee, Byung-Cheol
Jang, Hyeung-Jin
Lee, Hyejung
Jeong, Mi-Young
Lee, Kang-Min
Hong, Seung-Heon
Rim, Hong-Kun
Kim, Su-Jin
Um, Jae-Young
Lee, Kyung-Tae
Kim, Sung-Hoon
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Obesity is a metabolic disorder characterized by chronic inflammation and dyslipidemia and is a strong predictor for the development of hypertension, diabetes mellitus, and cardiovascular disease.
This study examined the antiobesity effect of an ethanol extract of Corni Fructus containing formulation (CDAP), which is a combination of four natural components: Corni Fructus, Dioscoreae Rhizoma, Aurantii Fructus Immaturus, and Platycodonis Radix.
The cellular lipid content in 3T3-L1 adipocytes was assessed by Oil Red O staining.
Expressions of peroxisome proliferator-activated receptor-γ (PPAR-γ), CCAAT/enhancer-binding protein-α (C/EBP-α), and lipin-1 were determined by real-time RT-PCR.
Western blot was used to determine the protein levels of PPAR-γ, C/EBP-α, and AMP-activated protein kinase-α (AMPK-α).
The CDAP extract suppressed the differentiation of 3T3-L1 adipocytes by downregulating cellular induction of PPAR-γ, C/EBP-α, and lipin-1.
The CDAP extract also significantly upregulated phosphorylation of AMPK-α.
An in vivo study showed that CDAP induced weight loss in mice with high-fat-diet-induced obesity.
These results indicate that CDAP has a potent anti-obesity effect due to the inhibition of adipocyte differentiation and adipogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Hye-Lin& Jeon, Yong-Deok& Park, Jinbong& Rim, Hong-Kun& Jeong, Mi-Young& Lim, Hara…[et al.]. 2013. Corni Fructus Containing Formulation Attenuates Weight Gain in Mice with Diet-Induced Obesity and Regulates Adipogenesis through AMPK. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-471034
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Hye-Lin…[et al.]. Corni Fructus Containing Formulation Attenuates Weight Gain in Mice with Diet-Induced Obesity and Regulates Adipogenesis through AMPK. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-471034
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Hye-Lin& Jeon, Yong-Deok& Park, Jinbong& Rim, Hong-Kun& Jeong, Mi-Young& Lim, Hara…[et al.]. Corni Fructus Containing Formulation Attenuates Weight Gain in Mice with Diet-Induced Obesity and Regulates Adipogenesis through AMPK. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-471034
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471034
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر