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The Prognostic Significance of the Preoperative Full Blood Count after Resection of Colorectal Liver Metastases
المؤلفون المشاركون
Wu, Andrew
Ghaneh, P.
De Liguori Carino, N.
O'Reilly, Derek A.
Dajani, K.
Poston, G.
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-09-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
Increased preoperative platelet and neutrophil counts are risk factors for decreased survival in several different malignancies.
Our aim was to investigate the relationship between overall or disease-free survival after resection of CRLM and the preoperative haematological parameters.
Methods.
We reviewed a cohort of 140 patients who underwent resection of CRLM with curative intent, utilising prospectively maintained databases.
Patient demographics, operative details, FBC, CRP, INR, histopathology results, and survival data were examined.
Kaplan-Meier survival and Cox regression analyses were used to determine the impact of all variables on survival.
Results.
140 patients (96 males) with a median age of 67 years (range 33–82 years) underwent resection of CRLM.
A significant correlation was exhibited between preoperative platelet count and neutrophil count (rho = 0.186, P=.028).
When modelled as continuous covariates in a Cox regression hazards, an increased preoperative platelet (P=.02) and neutrophil counts (P≤.001) were significantly associated with overall survival.
Of the haematological parameters assessed only preoperative platelet count showed a strong trend of association with disease free survival; however this failed to reach statistical significance (P=.076).
Conclusions.
Increased preoperative platelet and neutrophil counts are independent risk factors for decreased survival in patients undergoing resection of CRLM in our series of patients.
These findings require validation in larger studies to determine their relationship with survival.
Further research into the role of these cell types in tumour progression, particularly in the development and inhibition of angiogenesis, is warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dajani, K.& O'Reilly, Derek A.& De Liguori Carino, N.& Ghaneh, P.& Poston, G.& Wu, Andrew. 2009. The Prognostic Significance of the Preoperative Full Blood Count after Resection of Colorectal Liver Metastases. HPB Surgery،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-471151
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dajani, K.…[et al.]. The Prognostic Significance of the Preoperative Full Blood Count after Resection of Colorectal Liver Metastases. HPB Surgery No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-471151
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dajani, K.& O'Reilly, Derek A.& De Liguori Carino, N.& Ghaneh, P.& Poston, G.& Wu, Andrew. The Prognostic Significance of the Preoperative Full Blood Count after Resection of Colorectal Liver Metastases. HPB Surgery. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-471151
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471151
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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