Micronuclei in Bone Marrow and Liver in relation to Hepatic Metabolism and Antioxidant Response due to Coexposure to Chloroform, Dichloromethane, and Toluene in the Rat Model
المؤلفون المشاركون
Cárdenas-Rodríguez, Noemí
Belmont-Díaz, Javier
Arellano-Aguilar, Omar
López-Gordillo, Ana Paulina
Montero-Montoya, Regina D.
Coballase-Urrutia, Elvia
Serrano-García, Luis
Molina Garduño, Eunice
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-14
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Genotoxicity in cells may occur in different ways, direct interaction, production of electrophilic metabolites, and secondary genotoxicity via oxidative stress.
Chloroform, dichloromethane, and toluene are primarily metabolized in liver by CYP2E1, producing reactive electrophilic metabolites, and may also produce oxidative stress via the uncoupled CYP2E1 catalytic cycle.
Additionally, GSTT1 also participates in dichloromethane activation.
Despite the oxidative metabolism of these compounds and the production of oxidative adducts, their genotoxicity in the bone marrow micronucleus test is unclear.
The objective of this work was to analyze whether the oxidative metabolism induced by the coexposure to these compounds would account for increased micronucleus frequency.
We used an approach including the analysis of phase I, phase II, and antioxidant enzymes, oxidative stress biomarkers, and micronuclei in bone marrow (MNPCE) and hepatocytes (MNHEP).
Rats were administered different doses of an artificial mixture of CLF/DCM/TOL, under two regimes.
After one administration MNPCE frequency increased in correlation with induced GSTT1 activity and no oxidative stress occurred.
Conversely, after three-day treatments oxidative stress was observed, without genotoxicity.
The effects observed indicate that MNPCE by the coexposure to these VOCs could be increased via inducing the activity of metabolism enzymes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Belmont-Díaz, Javier& López-Gordillo, Ana Paulina& Molina Garduño, Eunice& Serrano-García, Luis& Coballase-Urrutia, Elvia& Cárdenas-Rodríguez, Noemí…[et al.]. 2014. Micronuclei in Bone Marrow and Liver in relation to Hepatic Metabolism and Antioxidant Response due to Coexposure to Chloroform, Dichloromethane, and Toluene in the Rat Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-471152
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Belmont-Díaz, Javier…[et al.]. Micronuclei in Bone Marrow and Liver in relation to Hepatic Metabolism and Antioxidant Response due to Coexposure to Chloroform, Dichloromethane, and Toluene in the Rat Model. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-471152
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Belmont-Díaz, Javier& López-Gordillo, Ana Paulina& Molina Garduño, Eunice& Serrano-García, Luis& Coballase-Urrutia, Elvia& Cárdenas-Rodríguez, Noemí…[et al.]. Micronuclei in Bone Marrow and Liver in relation to Hepatic Metabolism and Antioxidant Response due to Coexposure to Chloroform, Dichloromethane, and Toluene in the Rat Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-471152
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471152
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر