Literature-Based Discovery of IFN-γ and Vaccine-Mediated Gene Interaction Networks
المؤلفون المشاركون
Radev, Dragomir R.
Xiang, Zuoshuang
Özgür, Arzucan
He, Yongqun Oliver
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-06-03
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Interferon-gamma (IFN-γ) regulates various immune responses that are often critical for vaccine-induced protection.
In order to annotate the IFN-γ-related gene interaction network from a large amount of IFN-γ research reported in the literature, a literature-based discovery approach was applied with a combination of natural language processing (NLP) and network centrality analysis.
The interaction network of human IFN-γ (Gene symbol: IFNG) and its vaccine-specific subnetwork were automatically extracted using abstracts from all articles in PubMed.
Four network centrality metrics were further calculated to rank the genes in the constructed networks.
The resulting generic IFNG network contains 1060 genes and 26313 interactions among these genes.
The vaccine-specific subnetwork contains 102 genes and 154 interactions.
Fifty six genes such as TNF, NFKB1, IL2, IL6, and MAPK8 were ranked among the top 25 by at least one of the centrality methods in one or both networks.
Gene enrichment analysis indicated that these genes were classified in various immune mechanisms such as response to extracellular stimulus, lymphocyte activation, and regulation of apoptosis.
Literature evidence was manually curated for the IFN-γ relatedness of 56 genes and vaccine development relatedness for 52 genes.
This study also generated many new hypotheses worth further experimental studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Özgür, Arzucan& Xiang, Zuoshuang& Radev, Dragomir R.& He, Yongqun Oliver. 2010. Literature-Based Discovery of IFN-γ and Vaccine-Mediated Gene Interaction Networks. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-471289
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Özgür, Arzucan…[et al.]. Literature-Based Discovery of IFN-γ and Vaccine-Mediated Gene Interaction Networks. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-471289
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Özgür, Arzucan& Xiang, Zuoshuang& Radev, Dragomir R.& He, Yongqun Oliver. Literature-Based Discovery of IFN-γ and Vaccine-Mediated Gene Interaction Networks. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-471289
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471289
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر