Conservative Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw in Multiple Myeloma Patients
المؤلفون المشاركون
Melakopoulos, Ioannis
Tesseromatis, Christina
Terpos, Evangelos
Margaritis, Vasileios
Kastritis, Efstathios
Dimopoulos, Meletios-A.
Melea, Pelagia I.
المصدر
International Journal of Dentistry
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The use of intravenous bisphosphonates (pamidronate or zoledronic acid) is the cornerstone for the management of multiple myeloma-(MM-) related bone disease.
However, osteonecrosis of the jaw (ONJ) is a rare, but sometimes difficult to manage, adverse effect of bisphosphonates therapy.
A retrospective review of all MM patients who were treated with bisphosphonates in our department, from 2003 to 2013, and developed ONJ was performed.
According to inclusion criteria, 38 patients were studied.
All these patients were treated as conservatively as possible according to the American Association of Oral and Maxillofacial Surgeons criteria.
Patients were managed with observation, oral antibacterial mouth rinse with chlorhexidine, oral antibiotics, pain control with analgesics, nonsurgical sequestrectomy with or without simultaneous administration of antibiotics, or major surgery with or without antibiotics.
Healing of the lesions was achieved in 23 (60%) patients who were treated with conservative measures; the median time to healing was 12 months (95% CI: 4–21).
The number of bisphosphonates infusions influenced the time to healing: the median time to healing for patients who received <16 infusions was 7 months and for those with >16 infusions was it 14 months P=0.017.
We conclude that a primarily nonsurgical approach appears to be a successful management strategy for bisphosphonate-related ONJ.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Melea, Pelagia I.& Melakopoulos, Ioannis& Kastritis, Efstathios& Tesseromatis, Christina& Margaritis, Vasileios& Dimopoulos, Meletios-A.…[et al.]. 2014. Conservative Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw in Multiple Myeloma Patients. International Journal of Dentistry،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471363
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Melea, Pelagia I.…[et al.]. Conservative Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw in Multiple Myeloma Patients. International Journal of Dentistry No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-471363
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Melea, Pelagia I.& Melakopoulos, Ioannis& Kastritis, Efstathios& Tesseromatis, Christina& Margaritis, Vasileios& Dimopoulos, Meletios-A.…[et al.]. Conservative Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw in Multiple Myeloma Patients. International Journal of Dentistry. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471363
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471363
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر