RU28318, an Aldosterone Antagonist, in Combination with an ACE Inhibitor and Angiotensin Receptor Blocker Attenuates Cardiac Dysfunction in Diabetes
المؤلفون المشاركون
Babiker, Fawzi
Akhtar, Saghir
Yousif, Mariam
al-Rashdan, Ibrahim
Benter, Ibrahim F.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-27
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Aims.
We evaluated the effects of RU28318 (RU), a selective mineralocorticoid receptor (MR) antagonist, Captopril (Capt), an angiotensin converting enzyme inhibitor, and Losartan (Los), an angiotensin receptor blocker, alone or in combination with ischemia/reperfusion- (I/R-) induced cardiac dysfunction in hearts obtained from normal and diabetic rats.
Methods.
Isolated hearts were perfused for 30 min and then subjected to 30 min of global ischemia (I) followed by a period of 30 min of reperfusion (R).
Drugs were administered for 30 min either before or after ischemia.
Drug regimens tested were RU, Capt, Los, RU + Capt, RU + Los, Capt + Los, and RU + Capt + Los (Triple).
Recovery of cardiac hemodynamics was evaluated.
Results.
Recovery of cardiac function was up to 5-fold worse in hearts obtained from diabetic animals compared to controls.
Treatment with RU was generally better in preventing or reversing ischemia-induced cardiac dysfunction in normal hearts compared to treatment with Capt or Los alone.
In diabetic hearts, RU was generally similarly effective as Capt or Los treatment.
Conclusions.
RU treatment locally might be considered as an effective therapy or preventative measure in cardiac I/R injury.
Importantly, RU was the most effective at improving -dP/dt (a measure of diastolic function) when administered to diabetic hearts after ischemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Benter, Ibrahim F.& Babiker, Fawzi& al-Rashdan, Ibrahim& Yousif, Mariam& Akhtar, Saghir. 2013. RU28318, an Aldosterone Antagonist, in Combination with an ACE Inhibitor and Angiotensin Receptor Blocker Attenuates Cardiac Dysfunction in Diabetes. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-471402
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Benter, Ibrahim F.…[et al.]. RU28318, an Aldosterone Antagonist, in Combination with an ACE Inhibitor and Angiotensin Receptor Blocker Attenuates Cardiac Dysfunction in Diabetes. Journal of Diabetes Research No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-471402
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Benter, Ibrahim F.& Babiker, Fawzi& al-Rashdan, Ibrahim& Yousif, Mariam& Akhtar, Saghir. RU28318, an Aldosterone Antagonist, in Combination with an ACE Inhibitor and Angiotensin Receptor Blocker Attenuates Cardiac Dysfunction in Diabetes. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-471402
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471402
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر