A Novel Stent Coated with Antibodies to Endoglin Inhibits Neointimal Formation of Porcine Coronary Arteries
المؤلفون المشاركون
Liu, Jing-Hua
Cui, Song
Li, Kefeng
Lü, Shu-Zheng
Ma, Guo-Lin
Gao, Quan-Sheng
Du, Ben-Jun
Song, Xian-Tao
Meng, Li-Jun
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Endoglin/CD105 is an accessory protein of the transforming growth factor-β receptor system that plays a critical role in proliferation of endothelial cells and neovasculature.
Here, we aimed to assess the effect of novel stents coated with antibodies to endoglin (ENDs) on coronary neointima formation.
Thirty ENDs, thirty sirolimus-eluting stents (SESs), and thirty bare metal stents (BMSs) were randomly assigned and placed in the coronary arteries in 30 juvenile pigs.
Histomorphometric analysis and scanning electron microscopy were performed after stent implantation.
Our results showed that after 7 days, there was no difference in the neointimal area and percent area stenosis in ENDs compared with SMSs or BMSs.
After 14 days, the neointima area and percent area stenosis in ENDs were markedly decreased than those in BMSs or SESs (P<0.05).
Moreover, the percentage of reendothelialization was significantly higher in ENDs than that in SESs or BMSs (P<0.01) at 7 and 14 days.
The artery injury and the inflammation scores were similar in all groups at 7 and 14 days.
In conclusion, our results demonstrated for the first time to our knowledge that endoglin antibody-coated stents can markedly reduce restenosis by enhancing reendothelialization in the porcine model and potentially offer a new approach to prevent restenosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cui, Song& Liu, Jing-Hua& Song, Xian-Tao& Ma, Guo-Lin& Du, Ben-Jun& Lü, Shu-Zheng…[et al.]. 2014. A Novel Stent Coated with Antibodies to Endoglin Inhibits Neointimal Formation of Porcine Coronary Arteries. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471499
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cui, Song…[et al.]. A Novel Stent Coated with Antibodies to Endoglin Inhibits Neointimal Formation of Porcine Coronary Arteries. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-471499
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cui, Song& Liu, Jing-Hua& Song, Xian-Tao& Ma, Guo-Lin& Du, Ben-Jun& Lü, Shu-Zheng…[et al.]. A Novel Stent Coated with Antibodies to Endoglin Inhibits Neointimal Formation of Porcine Coronary Arteries. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471499
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471499
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر