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Complement Factor C7 Contributes to Lung Immunopathology Caused by Mycobacterium tuberculosis
المؤلفون المشاركون
Welsh, Kerry J.
Actor, Jeffrey K.
Boyd, Sydney
Braun, Michael C.
Lewis, Cole T.
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Mycobacterium tuberculosis (MTB) remains a significant global health burden despite the availability of antimicrobial chemotherapy.
Increasing evidence indicates a critical role of the complement system in the development of host protection against the bacillus, but few studies have specifically explored the function of the terminal complement factors.
Mice deficient in complement C7 and wild-type C57BL/6 mice were aerosol challenged with MTB Erdman and assessed for bacterial burden, histopathology, and lung cytokine responses at days 30 and 60 post-infection.
Macrophages isolated from C7 −/− and wild-type mice were evaluated for MTB proliferation and cytokine production.
C7 −/− mice had significantly less liver colony forming units (CFUs) at day 30; no differences were noted in lung CFUs.
The C7 deficient mice had markedly reduced lung occlusion with significantly increased total lymphocytes, decreased macrophages, and increased numbers of CD4+ cells 60 days post-infection.
Expression of lung IFN-γ and TNF-α was increased at day 60 compared to wild-type mice.
There were no differences in MTB-proliferation in macrophages isolated from wild-type and knock-out mice.
These results indicate a role for complement C7 in the development of MTB induced immunopathology which warrants further investigation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Welsh, Kerry J.& Lewis, Cole T.& Boyd, Sydney& Braun, Michael C.& Actor, Jeffrey K.. 2012. Complement Factor C7 Contributes to Lung Immunopathology Caused by Mycobacterium tuberculosis. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-471607
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Welsh, Kerry J.…[et al.]. Complement Factor C7 Contributes to Lung Immunopathology Caused by Mycobacterium tuberculosis. Clinical and Developmental Immunology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-471607
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Welsh, Kerry J.& Lewis, Cole T.& Boyd, Sydney& Braun, Michael C.& Actor, Jeffrey K.. Complement Factor C7 Contributes to Lung Immunopathology Caused by Mycobacterium tuberculosis. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-471607
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471607
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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