Glucose-6-Phosphate Dehydrogenase Activity and Protein Oxidative Modification in Patients with Type 2 Diabetes Mellitus
المؤلفون المشاركون
Nor El-Din, Amal K. A.
Mahmoud, Aida A.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
The aim of the present investigation was to study the activity of glucose-6-phosphate dehydrogenase (G6PD) and correlate its activity to protein oxidation markers in type 2 diabetic patients under poor glycemic control.
Methods.
G6PD activity, protein carbonyl group concentration, and total thiol group content were measured in blood samples of 40 patients with type 2 diabetes mellitus under poor glycemic control and 20 healthy control subjects.
Results.
G6PD activity and total thiol group content decreased significantly while glycated hemoglobin (HbA1C) and protein carbonyl group concentration increased significantly in diabetic patients than in the controls (P<0.001).
In addition, Obtained results revealed that, in diabetics, G6PD activity negatively correlated to protein carbonyl and HbA1C (r=−0.77 and −0.65, resp.), while positively correlated to total thiol (r=0.66) and protein carbonyl negatively correlated to total thiol (r=−0.85), while positively correlated to HbA1C (r=0.43).
Also in controls, G6PD activity negatively correlated to protein carbonyl and HbA1C (r=−0.57 and −0.56, resp.), while positively correlated to total thiol (r=0.5) and protein carbonyl negatively correlated to total thiol (r=−0.48), while positively correlated to HbA1C (r=0.68).
Conclusions.
We concluded that G6PD activity decreased in diabetics than in controls and was negatively correlated to oxidative stress markers and HbA1C.
G6PD activity can be taken as a biomarker of oxidative stress and poor glycemic control in type 2 diabetic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mahmoud, Aida A.& Nor El-Din, Amal K. A.. 2013. Glucose-6-Phosphate Dehydrogenase Activity and Protein Oxidative Modification in Patients with Type 2 Diabetes Mellitus. Journal of Biomarkers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-471704
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mahmoud, Aida A.& Nor El-Din, Amal K. A.. Glucose-6-Phosphate Dehydrogenase Activity and Protein Oxidative Modification in Patients with Type 2 Diabetes Mellitus. Journal of Biomarkers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-471704
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mahmoud, Aida A.& Nor El-Din, Amal K. A.. Glucose-6-Phosphate Dehydrogenase Activity and Protein Oxidative Modification in Patients with Type 2 Diabetes Mellitus. Journal of Biomarkers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-471704
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471704
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر