Cooperation of Nectin-1 and Nectin-3 Is Required for Maintenance of Epidermal Stratification and Proper Hair Shaft Formation in the Mouse
المؤلفون المشاركون
Thesleff, Irma
Yoshida, Toshiyuki
Takai, Yoshimi
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Nectins constitute a family of four cell adhesion molecules which are localized on cell membrane.
Mutations in NECTIN-1 gene cause the human ectodermal dysplasia syndrome (CLPED1) manifesting severe defects in skin and its appendages.
However, nectin-1 null mutant mice have only a mild defect in epidermal stratification suggesting compensation by other nectins.
We have analysed the epidermal and hair phenotypes of nectin-1; nectin-3 compound mutants.
Epidermis was fragile and displayed severe defects in stratification, hair follicles were hypoplastic, and hair shaft structure was abnormal.
Immunohistochemical analysis revealed severe defects in cell-cell junctions including adherens and tight junctions as well as desmosomes.
It is therefore likely that the phenotypes were caused by impaired cell adhesion.
The expression patterns of nectin-1 and nectin-3 together with the phenotypes in compound mutants indicated that heterophilic interactions between the two nectins are required for proper formation of epidermis and hair in mice.
The nectin-1; nectin-3 compound mutant mice partially reproduced the phenotype of human CLPED1 patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yoshida, Toshiyuki& Takai, Yoshimi& Thesleff, Irma. 2014. Cooperation of Nectin-1 and Nectin-3 Is Required for Maintenance of Epidermal Stratification and Proper Hair Shaft Formation in the Mouse. Developmental Biology Journal،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-471810
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yoshida, Toshiyuki…[et al.]. Cooperation of Nectin-1 and Nectin-3 Is Required for Maintenance of Epidermal Stratification and Proper Hair Shaft Formation in the Mouse. Developmental Biology Journal No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-471810
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yoshida, Toshiyuki& Takai, Yoshimi& Thesleff, Irma. Cooperation of Nectin-1 and Nectin-3 Is Required for Maintenance of Epidermal Stratification and Proper Hair Shaft Formation in the Mouse. Developmental Biology Journal. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-471810
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471810
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر