Early Growth Response Protein 1 Promotes Restenosis by Upregulating Intercellular Adhesion Molecule-1 in Vein Graft
المؤلفون المشاركون
Zhang, Kui
Dong, Ran
Du, Jie
Cao, Jian
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Objectives.
To verify the relationship between Egr-1 and vein graft restenosis and investigate the related mechanisms.
Methods.
Mouse vein graft models were established in Egr-1 knockout (KO) and wild-type (WT) mice.
The vein grafts in the mice were taken for pathological examination and immunohistochemical analysis.
The endothelial cells (ECs) were stimulated by using a computer-controlled cyclic stress unit.
BrdU staining and PCR were used to detect ECs proliferation activity and Egr-1 and ICAM-1 mRNA expression, respectively.
Western-blot analysis was also used to detect expression of Egr-1 and intercellular adhesion molecule-1 (ICAM-1) proteins.
Results.
The lumens of vein grafts in Egr-1 KO mice were wider than in WT mice.
ECs proliferation after mechanical stretch stimulation was suppressed by Egr-1 knockout (P<0.05).
Both in vein grafts and ECs from WT mice after mechanical stretch stimulation, mRNA expression and protein of Egr-1 and ICAM-1 showed increases (P<0.05).
However, ICAM-1 expression was significantly suppressed in ECs from Egr-1 knockout mice (P<0.05).
Conclusions.
Egr-1 may promote ECs proliferation and result in vein graft restenosis by upregulating the expression of ICAM-1.
As a key factor of vein graft restenosis, it could be a target for the prevention of restenosis after CABG surgery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Kui& Cao, Jian& Dong, Ran& Du, Jie. 2013. Early Growth Response Protein 1 Promotes Restenosis by Upregulating Intercellular Adhesion Molecule-1 in Vein Graft. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-471843
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Kui…[et al.]. Early Growth Response Protein 1 Promotes Restenosis by Upregulating Intercellular Adhesion Molecule-1 in Vein Graft. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-471843
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Kui& Cao, Jian& Dong, Ran& Du, Jie. Early Growth Response Protein 1 Promotes Restenosis by Upregulating Intercellular Adhesion Molecule-1 in Vein Graft. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-471843
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471843
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر