A Sensitive and Selective Method for Determination of Aesculin in Cortex Fraxini by Liquid Chromatography Quadrupole Time-of-Flight Tandem Mass Spectrometry and Application in Pharmacokinetic Study
المؤلفون المشاركون
Geng, Qianqian
Wu, Yinying
Li, Enxiao
Wu, Huili
Li, Yi
Dong, Danfeng
Guo, Hui
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
A rapid and sensitive method for determining aesculin of Cortex fraxini in rat was developed using high-performance liquid chromatography (HPLC) quadrupole time-of-flight (QTOF) tandem mass (MS/MS).
Rat plasma was pretreated by fourfold methanol to remove plasma proteins.
Chromatographic separation was performed on a reverse phase column.
A tandem mass spectrometric detection with an electrospray ionization (ESI) interface was achieved using collision-induced dissociation (CID) under positive ionization mode.
The MS/MS patterns monitored were m/z 341.2716 → m/z 179.1043 for aesculin and m/z 248.3025 → m/z 120.9130 for tinidazole (internal standard).
The linear range was calculated to be 10.0–1500.0 ng/mL with a detection limit of 2.0 ng/mL.
The inter- and intraday accuracy and precision were within ±7.0%.
Pharmacokinetic study showed that aesculin was confirmed to be a one-compartment open model.
The method is believed to have good linear range, high sensitivity and recoveries, and superior analytical efficiency.
It will probably be an alternative for pharmacokinetic study of aesculin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yi& Guo, Hui& Wu, Yinying& Geng, Qianqian& Dong, Danfeng& Wu, Huili…[et al.]. 2013. A Sensitive and Selective Method for Determination of Aesculin in Cortex Fraxini by Liquid Chromatography Quadrupole Time-of-Flight Tandem Mass Spectrometry and Application in Pharmacokinetic Study. Journal of Analytical Methods in Chemistry،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-471846
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yi…[et al.]. A Sensitive and Selective Method for Determination of Aesculin in Cortex Fraxini by Liquid Chromatography Quadrupole Time-of-Flight Tandem Mass Spectrometry and Application in Pharmacokinetic Study. Journal of Analytical Methods in Chemistry No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-471846
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yi& Guo, Hui& Wu, Yinying& Geng, Qianqian& Dong, Danfeng& Wu, Huili…[et al.]. A Sensitive and Selective Method for Determination of Aesculin in Cortex Fraxini by Liquid Chromatography Quadrupole Time-of-Flight Tandem Mass Spectrometry and Application in Pharmacokinetic Study. Journal of Analytical Methods in Chemistry. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-471846
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471846
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر