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Long-Term Outcome of an HIV-Treatment Programme in Rural Africa : Viral Suppression despite Early Mortality
المؤلفون المشاركون
Hoepelman, Andy I. M.
Tempelman, Hugo A.
Moraba, Robert
Barth, Roos E.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-11-21
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
To define the long-term (2–4 years) clinical and virological outcome of an antiretroviral treatment (ART) programme in rural South Africa.
Methods.
We performed a retrospective observational cohort study, including 735 patients who initiated ART.
Biannual monitoring, including HIV-RNA testing, was performed.
Primary endpoint was patient retention; virological suppression (HIV-RNA < 50 copies/mL) and failure (HIV-RNA > 1000 copies/mL) were secondary endpoints.
Moreover, possible predictors of treatment failure were analyzed.
Results.
63% of patients (466/735) have a fully suppressed HIV-RNA, a median of three years after treatment initiation.
Early mortality was high: 14% died within 3 months after treatment start.
16% of patients experienced virological failure, but only 4% was switched to second-line ART.
Male gender and a low performance score were associated with treatment failure; immunological failure was a poor predictor of virological failure.
Conclusions.
An “all or nothing” phenomenon was observed in this rural South African ART programme: high early attrition, but good virological control in those remaining in care.
Continued efforts are needed to enrol patients earlier.
Furthermore, the observed viro-immunological dissociation emphasises the need to make HIV-RNA testing more widely available.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barth, Roos E.& Tempelman, Hugo A.& Moraba, Robert& Hoepelman, Andy I. M.. 2010. Long-Term Outcome of an HIV-Treatment Programme in Rural Africa : Viral Suppression despite Early Mortality. AIDS Research and Treatment،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-471938
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barth, Roos E.…[et al.]. Long-Term Outcome of an HIV-Treatment Programme in Rural Africa : Viral Suppression despite Early Mortality. AIDS Research and Treatment No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-471938
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barth, Roos E.& Tempelman, Hugo A.& Moraba, Robert& Hoepelman, Andy I. M.. Long-Term Outcome of an HIV-Treatment Programme in Rural Africa : Viral Suppression despite Early Mortality. AIDS Research and Treatment. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-471938
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471938
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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