Long-Term Outcome of an HIV-Treatment Programme in Rural Africa : Viral Suppression despite Early Mortality
المؤلفون المشاركون
Hoepelman, Andy I. M.
Tempelman, Hugo A.
Moraba, Robert
Barth, Roos E.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-11-21
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
To define the long-term (2–4 years) clinical and virological outcome of an antiretroviral treatment (ART) programme in rural South Africa.
Methods.
We performed a retrospective observational cohort study, including 735 patients who initiated ART.
Biannual monitoring, including HIV-RNA testing, was performed.
Primary endpoint was patient retention; virological suppression (HIV-RNA < 50 copies/mL) and failure (HIV-RNA > 1000 copies/mL) were secondary endpoints.
Moreover, possible predictors of treatment failure were analyzed.
Results.
63% of patients (466/735) have a fully suppressed HIV-RNA, a median of three years after treatment initiation.
Early mortality was high: 14% died within 3 months after treatment start.
16% of patients experienced virological failure, but only 4% was switched to second-line ART.
Male gender and a low performance score were associated with treatment failure; immunological failure was a poor predictor of virological failure.
Conclusions.
An “all or nothing” phenomenon was observed in this rural South African ART programme: high early attrition, but good virological control in those remaining in care.
Continued efforts are needed to enrol patients earlier.
Furthermore, the observed viro-immunological dissociation emphasises the need to make HIV-RNA testing more widely available.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barth, Roos E.& Tempelman, Hugo A.& Moraba, Robert& Hoepelman, Andy I. M.. 2010. Long-Term Outcome of an HIV-Treatment Programme in Rural Africa : Viral Suppression despite Early Mortality. AIDS Research and Treatment،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-471938
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barth, Roos E.…[et al.]. Long-Term Outcome of an HIV-Treatment Programme in Rural Africa : Viral Suppression despite Early Mortality. AIDS Research and Treatment No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-471938
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barth, Roos E.& Tempelman, Hugo A.& Moraba, Robert& Hoepelman, Andy I. M.. Long-Term Outcome of an HIV-Treatment Programme in Rural Africa : Viral Suppression despite Early Mortality. AIDS Research and Treatment. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-471938
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471938
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر