Bimodal Porous Scaffolds by Sequential Electrospinning of Poly(glycolic acid) with Sucrose Particles
المؤلفون المشاركون
Kao, K. K.
Stelzner, M.
Agopian, V. G.
Ahn, A.
Wu, B. M.
Dunn, J. C.
Wulkersdorfer, B.
المصدر
International Journal of Polymer Science
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-03-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Electrospinning is a method to produce fine, biopolymer mesh with a three-dimensional architecture that mimics native extra-cellular matrix.
Due to the small fiber diameter created in this process, conventional electrospun scaffolds have pore sizes smaller than the diameter of most cells.
These scaffolds have limited application in tissue engineering due to poor cell penetration.
We developed a hybrid electrospinning/particulate leaching technique to create scaffolds with increased porosity and improved cellular ingrowth.
Poly(glycolic acid) (PGA) and a sucrose-ethanol suspension were electrospun in equal, alternating sequences at intervals of one, two, and ten minutes each.
The scaffolds revealed fiber mesh with micropores of 10 μm and uniformly distributed sucrose particles.
Particulate leaching of sucrose from the one- or two-minute scaffolds revealed honeycomb structures with interconnected macropores between 50 and 250 μm.
Sucrose leaching from the ten-minute scaffolds resulted in laminated structures with isolated macropores between 200 and 350 μm.
Macropore size was directly proportional to the duration of the sucrose spinning interval.
After 24 hours of cell culture, conventionally spun scaffolds demonstrated no cellular penetration.
Conversely, the PGA/sucrose scaffolds demonstrated deep cellular penetration.
This hybrid technique represents a novel method of generating electrospun scaffolds with interconnected pores suitable for cellular ingrowth.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wulkersdorfer, B.& Kao, K. K.& Agopian, V. G.& Ahn, A.& Dunn, J. C.& Wu, B. M.…[et al.]. 2010. Bimodal Porous Scaffolds by Sequential Electrospinning of Poly(glycolic acid) with Sucrose Particles. International Journal of Polymer Science،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-472109
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wulkersdorfer, B.…[et al.]. Bimodal Porous Scaffolds by Sequential Electrospinning of Poly(glycolic acid) with Sucrose Particles. International Journal of Polymer Science No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-472109
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wulkersdorfer, B.& Kao, K. K.& Agopian, V. G.& Ahn, A.& Dunn, J. C.& Wu, B. M.…[et al.]. Bimodal Porous Scaffolds by Sequential Electrospinning of Poly(glycolic acid) with Sucrose Particles. International Journal of Polymer Science. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-472109
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472109
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر