HPV Prevalence and Prognostic Value in a Prospective Cohort of 255 Patients with Locally Advanced HNSCC : A Single-Centre Experience
المؤلفون المشاركون
Soulières, Denis
Christopoulos, A.
Tabet, Jean-Claude
Weng, Xiaoduan
Coutlée, F.
Guertin, Louis
Thibaudeau, Ève
Audet, Marie-Lise
Fortin, Bernard
Abboud, O.
Nguyen-Tan, Phuc Félix
المصدر
International Journal of Otolaryngology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
HPV is a positive prognostic factor in HNSCC.
We studied the prevalence and prognostic impact of HPV on survival parameters and treatment toxicity in patients with locally advanced HNSCC treated with concomitant chemoradiation therapy.
Methods.
Data on efficacy and toxicity were available for 560 patients.
HPV was detected by PCR.
Analysis was performed using Kaplan-Meier survival curves, Fisher’s test for categorical data, and log-rank statistics for failure times.
Results.
Median follow-up was 4.7 years.
DNA extraction was successful in 255 cases.
HPV prevalence was 68.6%, and 53.3% for HPV 16.
For HPV+ and HPV−, median LRC was 8.9 and 2.2 years (P=0.0002), median DFS was 8.9 and 2.1 years (P=0.0014), and median OS was 8.9 and 3.1 years (P=0.0002).
Survival was different based on HPV genotype, stage, treatment period, and chemotherapy regimen.
COX adjusted analysis for T, N, age, and treatment remained significant (P=0.004).
Conclusions.
Oropharyngeal cancer is increasingly linked to HPV.
This study confirms that HPV status is associated with improved prognosis among H&N cancer patients receiving CRT and should be a stratification factor for clinical trials including H&N cases.
Toxicity of CRT is not modified for the HPV population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Thibaudeau, Ève& Fortin, Bernard& Coutlée, F.& Nguyen-Tan, Phuc Félix& Weng, Xiaoduan& Audet, Marie-Lise…[et al.]. 2013. HPV Prevalence and Prognostic Value in a Prospective Cohort of 255 Patients with Locally Advanced HNSCC : A Single-Centre Experience. International Journal of Otolaryngology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-472295
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Thibaudeau, Ève…[et al.]. HPV Prevalence and Prognostic Value in a Prospective Cohort of 255 Patients with Locally Advanced HNSCC : A Single-Centre Experience. International Journal of Otolaryngology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-472295
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Thibaudeau, Ève& Fortin, Bernard& Coutlée, F.& Nguyen-Tan, Phuc Félix& Weng, Xiaoduan& Audet, Marie-Lise…[et al.]. HPV Prevalence and Prognostic Value in a Prospective Cohort of 255 Patients with Locally Advanced HNSCC : A Single-Centre Experience. International Journal of Otolaryngology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-472295
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472295
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر