Stromal Expression of CD10 in Invasive Breast Carcinoma and Its Correlation with ER, PR, HER2-neu, and Ki67
المؤلفون المشاركون
Thomas, Shaji
Jain, Manjula
Puri, Vandana
المصدر
International Journal of Breast Cancer
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-16
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
CD10 is a cell surface zinc-dependent endopeptidase, which degrades many bioactive peptides.
CD10 expression in tumour stroma is associated with biological aggressiveness of many epithelial malignancies.
To date, only one study has correlated with expression of CD10 with well-known prognostic markers of breast, that is, ER, PR, HER2-neu, and tumour grade; however, its correlation with ki67 is still not studied.
The aim of this study is to evaluate stromal CD10 expression in breast carcinoma and to examine its correlation with ER, PR, HER2-neu, and Ki67.
Methods and Results.
CD10 expression in fifty patients was assessed by immunohistochemistry and scored as negative, weak and strong.
CD10 was found to be positive in stroma of 40/50 (80%) cases.
Stromal CD10 showed positive correlation with tumour grade, HER2-neu (P=.000), and ki67 (P=.027), negative correlation with ER and PR.
Conclusions.
Hence CD10 expression correlated strongly with well-established negative prognostic markers, that is, HER2-neu and ki67 positivity, ER/PR negativity, and higher tumour grade, thus indicating that CD10 can be used as independent marker indicating poor prognosis and can be used as target for the development of novel therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Puri, Vandana& Jain, Manjula& Thomas, Shaji. 2011. Stromal Expression of CD10 in Invasive Breast Carcinoma and Its Correlation with ER, PR, HER2-neu, and Ki67. International Journal of Breast Cancer،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-472313
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Puri, Vandana…[et al.]. Stromal Expression of CD10 in Invasive Breast Carcinoma and Its Correlation with ER, PR, HER2-neu, and Ki67. International Journal of Breast Cancer No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-472313
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Puri, Vandana& Jain, Manjula& Thomas, Shaji. Stromal Expression of CD10 in Invasive Breast Carcinoma and Its Correlation with ER, PR, HER2-neu, and Ki67. International Journal of Breast Cancer. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-472313
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472313
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر