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Induction of Granulysin and Perforin Cytolytic Mediator Expression in 10-Week-Old Infants Vaccinated with BCG at Birth
المؤلفون المشاركون
Semple, Patricia L.
Ress, Stanley
Watkins, Marcia
Kaplan, Gilla
Krensky, Alan M.
Davids, Virginia
Hanekom, Willem A.
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
While vaccination at birth with Mycobacterium bovis Bacilli Calmette-Guérin (BCG) protects against severe childhood tuberculosis, there is no consensus as to which components of the BCG-induced immune response mediate this protection.
However, granulysin and perforin, found in the granules of cytotoxic T lymphocytes and Natural Killer (NK) cells, can kill intracellular mycobacteria and are implicated in protection against Mycobacterium tuberculosis.
Methods.
We compared the cellular expression of granulysin and perforin cytolytic molecules in cord blood and peripheral blood from 10-week-old infants vaccinated at birth with either Japanese or Danish BCG, administered either intradermally or percutaneously.
Results.
In cord blood, only CD56+ NK cells expressed granulysin and perforin constitutively.
These cytolytic mediators were upregulated in CD4+ and CD8+ cord blood cells by ex vivo stimulation with BCG but not with PPD.
Following BCG vaccination of neonates, both BCG and PPD induced increased expression of granulysin and perforin by CD4+ and CD8+ T cells.
There was no difference in expression of cytolytic molecules according to vaccination route or strain.
Conclusions.
Constitutive expression of perforin and granulysin by cord blood NK-cells likely provides innate immunity, while BCG vaccination-induced expression of these cytolytic mediators may contribute towards protection of the neonate against tuberculosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Semple, Patricia L.& Watkins, Marcia& Davids, Virginia& Krensky, Alan M.& Hanekom, Willem A.& Kaplan, Gilla…[et al.]. 2010. Induction of Granulysin and Perforin Cytolytic Mediator Expression in 10-Week-Old Infants Vaccinated with BCG at Birth. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-472351
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Semple, Patricia L.…[et al.]. Induction of Granulysin and Perforin Cytolytic Mediator Expression in 10-Week-Old Infants Vaccinated with BCG at Birth. Clinical and Developmental Immunology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-472351
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Semple, Patricia L.& Watkins, Marcia& Davids, Virginia& Krensky, Alan M.& Hanekom, Willem A.& Kaplan, Gilla…[et al.]. Induction of Granulysin and Perforin Cytolytic Mediator Expression in 10-Week-Old Infants Vaccinated with BCG at Birth. Clinical and Developmental Immunology. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-472351
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472351
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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